Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy

Cancer chemotherapy can benefit from the combination of different anticancer drugs. Here, we prepared doxorubicin (Dox)- and thioridazine (Thio)-coloaded methoxy poly(ethylene glycol)-poly(l-lactic acid) (MPEG-PLA) nanoparticles (NPs) for breast cancer therapy. These NPs have an average particle siz...

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Detalles Bibliográficos
Autores principales: Jin, Xun, Zou, Bingwen, Luo, Li, Zhong, Chuanhong, Zhang, Peilan, Cheng, Hao, Guo, Yanfang, Gou, Maling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019472/
https://www.ncbi.nlm.nih.gov/pubmed/27660446
http://dx.doi.org/10.2147/IJN.S104635
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author Jin, Xun
Zou, Bingwen
Luo, Li
Zhong, Chuanhong
Zhang, Peilan
Cheng, Hao
Guo, Yanfang
Gou, Maling
author_facet Jin, Xun
Zou, Bingwen
Luo, Li
Zhong, Chuanhong
Zhang, Peilan
Cheng, Hao
Guo, Yanfang
Gou, Maling
author_sort Jin, Xun
collection PubMed
description Cancer chemotherapy can benefit from the combination of different anticancer drugs. Here, we prepared doxorubicin (Dox)- and thioridazine (Thio)-coloaded methoxy poly(ethylene glycol)-poly(l-lactic acid) (MPEG-PLA) nanoparticles (NPs) for breast cancer therapy. These NPs have an average particle size of 27 nm. The drug loading efficiencies of Thio and Dox are 4.71% and 1.98%, respectively. Compared to the treatment of Thio or Dox alone, the combination of Thio and Dox exhibited a synergistic effect in inhibiting the growth of 4T1 breast cancer cells in vitro. In addition, the Thio- and Dox-coloaded MPEG-PLA NPs could efficiently suppress the growth of breast cancer cells in vivo. This study suggests that Thio- and Dox-coloaded MPEG-PLA NPs might have potential applications in breast cancer treatment.
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spelling pubmed-50194722016-09-22 Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy Jin, Xun Zou, Bingwen Luo, Li Zhong, Chuanhong Zhang, Peilan Cheng, Hao Guo, Yanfang Gou, Maling Int J Nanomedicine Original Research Cancer chemotherapy can benefit from the combination of different anticancer drugs. Here, we prepared doxorubicin (Dox)- and thioridazine (Thio)-coloaded methoxy poly(ethylene glycol)-poly(l-lactic acid) (MPEG-PLA) nanoparticles (NPs) for breast cancer therapy. These NPs have an average particle size of 27 nm. The drug loading efficiencies of Thio and Dox are 4.71% and 1.98%, respectively. Compared to the treatment of Thio or Dox alone, the combination of Thio and Dox exhibited a synergistic effect in inhibiting the growth of 4T1 breast cancer cells in vitro. In addition, the Thio- and Dox-coloaded MPEG-PLA NPs could efficiently suppress the growth of breast cancer cells in vivo. This study suggests that Thio- and Dox-coloaded MPEG-PLA NPs might have potential applications in breast cancer treatment. Dove Medical Press 2016-09-08 /pmc/articles/PMC5019472/ /pubmed/27660446 http://dx.doi.org/10.2147/IJN.S104635 Text en © 2016 Jin et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Jin, Xun
Zou, Bingwen
Luo, Li
Zhong, Chuanhong
Zhang, Peilan
Cheng, Hao
Guo, Yanfang
Gou, Maling
Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy
title Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy
title_full Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy
title_fullStr Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy
title_full_unstemmed Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy
title_short Codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy
title_sort codelivery of thioridazine and doxorubicin using nanoparticles for effective breast cancer therapy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019472/
https://www.ncbi.nlm.nih.gov/pubmed/27660446
http://dx.doi.org/10.2147/IJN.S104635
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