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Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct

Nuclear hormone receptors (NHRs) are transcription factors that regulate numerous physiological and developmental processes and represent important drug targets. NHR-49, an ortholog of Hepatocyte Nuclear Factor 4 (HNF4), has emerged as a key regulator of lipid metabolism and life span in the nematod...

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Detalles Bibliográficos
Autores principales:	Lee, Kayoung, Goh, Grace Ying Shyen, Wong, Marcus Andrew, Klassen, Tara Leah, Taubert, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019492/ https://www.ncbi.nlm.nih.gov/pubmed/27618178 http://dx.doi.org/10.1371/journal.pone.0162708

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