Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy

The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clin...

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Detalles Bibliográficos
Autores principales: Arutyunyan, Irina, Elchaninov, Andrey, Makarov, Andrey, Fatkhudinov, Timur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019943/
https://www.ncbi.nlm.nih.gov/pubmed/27651799
http://dx.doi.org/10.1155/2016/6901286
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author Arutyunyan, Irina
Elchaninov, Andrey
Makarov, Andrey
Fatkhudinov, Timur
author_facet Arutyunyan, Irina
Elchaninov, Andrey
Makarov, Andrey
Fatkhudinov, Timur
author_sort Arutyunyan, Irina
collection PubMed
description The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived from the umbilical cord, in cell transplantation are associated with the need for specialized biobanking and transplant standardization criteria.
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spelling pubmed-50199432016-09-20 Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy Arutyunyan, Irina Elchaninov, Andrey Makarov, Andrey Fatkhudinov, Timur Stem Cells Int Review Article The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived from the umbilical cord, in cell transplantation are associated with the need for specialized biobanking and transplant standardization criteria. Hindawi Publishing Corporation 2016 2016-08-29 /pmc/articles/PMC5019943/ /pubmed/27651799 http://dx.doi.org/10.1155/2016/6901286 Text en Copyright © 2016 Irina Arutyunyan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Arutyunyan, Irina
Elchaninov, Andrey
Makarov, Andrey
Fatkhudinov, Timur
Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
title Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
title_full Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
title_fullStr Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
title_full_unstemmed Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
title_short Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy
title_sort umbilical cord as prospective source for mesenchymal stem cell-based therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019943/
https://www.ncbi.nlm.nih.gov/pubmed/27651799
http://dx.doi.org/10.1155/2016/6901286
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AT makarovandrey umbilicalcordasprospectivesourceformesenchymalstemcellbasedtherapy
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