Cargando…

Targeting Cannabinoid CB(2) Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs), namely cannabinoid CB(1) and CB(2). Contrary to the psychotropic actions of agonists of CB(1) receptors, and serious side effects of the selective antagonists of this receptor, drugs acting on CB(2) receptors appear...

Descripción completa

Detalles Bibliográficos
Autores principales:	Navarro, Gemma, Morales, Paula, Rodríguez-Cueto, Carmen, Fernández-Ruiz, Javier, Jagerovic, Nadine, Franco, Rafael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020102/ https://www.ncbi.nlm.nih.gov/pubmed/27679556 http://dx.doi.org/10.3389/fnins.2016.00406

Ejemplares similares

The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB(2) Receptors
por: Franco, Rafael, et al.
Publicado: (2022)

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB(2) Receptor
por: Morales, Paula, et al.
Publicado: (2020)

Allosteric Modulators of the CB(1) Cannabinoid Receptor: A Structural Update Review
por: Morales, Paula, et al.
Publicado: (2016)

Antitumor Cannabinoid Chemotypes: Structural Insights
por: Morales, Paula, et al.
Publicado: (2019)

Cannabigerol Action at Cannabinoid CB(1) and CB(2) Receptors and at CB(1)–CB(2) Heteroreceptor Complexes
por: Navarro, Gemma, et al.
Publicado: (2018)

Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators
por: Morales, Paula, et al.
Publicado: (2022)

Benzyl-1,2,4-triazoles as CB(1) Cannabinoid Receptor Ligands: Preparation and In Vitro Pharmacological Evaluation
por: Hernandez-Folgado, Laura, et al.
Publicado: (2016)

N-Methyl-D-aspartate (NMDA) and cannabinoid CB(2) receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors
por: Rivas-Santisteban, Rafael, et al.
Publicado: (2021)

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
por: Morales, Paula, et al.
Publicado: (2017)

Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential
por: Vuic, Barbara, et al.
Publicado: (2022)

An Update on Non-CB(1), Non-CB(2) Cannabinoid Related G-Protein-Coupled Receptors
por: Morales, Paula, et al.
Publicado: (2017)

Editorial: The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
por: Contino, Marialessandra, et al.
Publicado: (2017)

Spatial distribution of cannabinoid receptor type 1 (CB(1)) in normal canine central and peripheral nervous system
por: Freundt-Revilla, Jessica, et al.
Publicado: (2017)

Neuronal Calcium and cAMP Cross-Talk Mediated by Cannabinoid CB(1) Receptor and EF-Hand Calcium Sensor Interactions
por: Angelats, Edgar, et al.
Publicado: (2018)

A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB(2) Receptor via the Lipid Bilayer
por: Casajuana-Martin, Nil, et al.
Publicado: (2022)

The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone‐Induced Central Nervous System Demyelination
por: Tomas‐Roig, Jordi, et al.
Publicado: (2016)

Regulation of Expression of Cannabinoid CB(2) and Serotonin 5HT(1A) Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen/Glucose-Deprived Neurons
por: Lillo, Jaume, et al.
Publicado: (2022)

Methamphetamine Blocks Adenosine A(2A) Receptor Activation via Sigma 1 and Cannabinoid CB(1) Receptors
por: Casanovas, Mireia, et al.
Publicado: (2021)

Cannabinoid CB(1) and CB(2) Receptor Signaling and Bias
por: Ibsen, Mikkel Søes, et al.
Publicado: (2017)

Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB(2) Receptors
por: Martínez-Pinilla, Eva, et al.
Publicado: (2017)

Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration
por: Galán-Ganga, M., et al.
Publicado: (2021)

Cannabinoid-based drugs targeting CB(1) and TRPV1, the sympathetic nervous system, and arthritis
por: Lowin, Torsten, et al.
Publicado: (2015)

Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB(1) Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet
por: Lillo, Alejandro, et al.
Publicado: (2021)

Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System
por: Franco, Rafael, et al.
Publicado: (2019)

Identification of the Ghrelin and Cannabinoid CB(2) Receptor Heteromer Functionality and Marked Upregulation in Striatal Neurons from Offspring of Mice under a High-Fat Diet
por: Lillo, Jaume, et al.
Publicado: (2021)

Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells
por: Jiang, Shuxian, et al.
Publicado: (2007)

The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation
por: Bow, Eric W., et al.
Publicado: (2016)

Cannabinoid CB1 receptors regulate salivation
por: Andreis, Kelsey, et al.
Publicado: (2022)

Voltage dependence of the cannabinoid CB1 receptor
por: Goldberger, Esty, et al.
Publicado: (2022)

Cannabinoid CB(2) receptors in the mouse brain: relevance for Alzheimer’s disease
por: López, Alicia, et al.
Publicado: (2018)

CB(1) and LPA(1) Receptors Relationship in the Mouse Central Nervous System
por: González de San Román, Estíbaliz, et al.
Publicado: (2019)

Detection of Heteromers Formed by Cannabinoid CB(1), Dopamine D(2), and Adenosine A(2A) G-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer
por: Navarro, Gemma, et al.
Publicado: (2008)

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys
por: Bouskila, Joseph, et al.
Publicado: (2016)

Circuit Specific Functions of Cannabinoid CB1 Receptor in the Balance of Investigatory Drive and Exploration
por: Häring, Martin, et al.
Publicado: (2011)

Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism
por: Sierra, Salvador, et al.
Publicado: (2014)

Cannabinoid Receptor CB(2) Modulates Axon Guidance
por: Duff, Gabriel, et al.
Publicado: (2013)

CB1 Cannabinoid Receptor Signaling and Biased Signaling
por: Leo, Luciana M., et al.
Publicado: (2021)

Editorial: Therapeutic potential of the cannabinoid CB2 receptor
por: Smoum, Reem, et al.
Publicado: (2022)

Microglial Cannabinoid CB(2) Receptors in Pain Modulation
por: Xu, Kangtai, et al.
Publicado: (2023)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB(2) receptor
por: Patel, Monica, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d2ei319lq0nmcg997kqn9egn27