Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33

A new paradigm for understanding immune-surveillance and immune escape in cancer is described here. Metastatic carcinomas express reduced levels of IL-33 and diminished levels of antigen processing machinery (APM), compared to syngeneic primary tumours. Complementation of IL-33 expression in metasta...

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Detalles Bibliográficos
Autores principales: Saranchova, Iryna, Han, Jeffrey, Huang, Hui, Fenninger, Franz, Choi, Kyung Bok, Munro, Lonna, Pfeifer, Cheryl, Welch, Ian, Wyatt, Alexander W., Fazli, Ladan, Gleave, Martin E., Jefferies, Wilfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020406/
https://www.ncbi.nlm.nih.gov/pubmed/27619158
http://dx.doi.org/10.1038/srep30555

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