Cargando…

A phase-I trial of pre‐operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer: the ‘SPARC’ trial protocol

BACKGROUND: Standard therapy for borderline-resectable pancreatic cancer in the UK is surgery with adjuvant chemotherapy, but rates of resection with clear margins are unsatisfactory and overall survival remains poor. Meta-analysis of single-arm studies shows the potential of neo-adjuvant chemo-radi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holyoake, Daniel L. P., Ward, Elizabeth, Grose, Derek, McIntosh, David, Sebag-Montefiore, David, Radhakrishna, Ganesh, Patel, Neel, Silva, Michael, Mukherjee, Somnath, Strauss, Victoria Y., Odondi, Lang’o, Fokas, Emmanouil, Melcher, Alan, Hawkins, Maria A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020462/ https://www.ncbi.nlm.nih.gov/pubmed/27619800 http://dx.doi.org/10.1186/s12885-016-2765-4

Ejemplares similares

Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer
por: Holyoake, Daniel L.P., et al.
Publicado: (2016)

Patient-reported outcomes in PROSPECT trial (Alliance N1048) – FOLFOX is not a panacea
por: O'Cathail, Sean M., et al.
Publicado: (2023)

Design, analysis and reporting of active-control randomised trials: a systematic review
por: Odondi, Lang'o, et al.
Publicado: (2013)

Concurrent chemoradiotherapy for squamous cell carcinoma of the anus using a shrinking field radiotherapy technique without a boost
por: Melcher, A A, et al.
Publicado: (2003)

Stereotactic radiotherapy with focal boost for intermediate and high-risk prostate cancer: Initial results of the SPARC trial
por: Nicholls, Luke, et al.
Publicado: (2020)

Liver Stereotactic Ablative Radiotherapy: an Effective and Feasible Alternative to Surgery during the COVID-19 Pandemic
por: Aitken, K., et al.
Publicado: (2020)

Comparison of investigator-delineated gross tumour volumes and quality assurance in pancreatic cancer: Analysis of the on-trial cases for the SCALOP trial
por: Fokas, Emmanouil, et al.
Publicado: (2016)

Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2)
por: Strauss, Victoria Y., et al.
Publicado: (2019)

Radiotherapy for rectal cancer: Short course versus long course – When and how
por: Sebag-Montefiore, David
Publicado: (2013)

Oxaliplatin/capecitabine or carboplatin/paclitaxel-based preoperative chemoradiation for resectable oesophageal adenocarcinoma (NeoSCOPE): Long-term results of a randomised controlled trial
por: Mukherjee, Somnath, et al.
Publicado: (2021)

Preoperative radiotherapy combined with 5 days per week capecitabine chemotherapy in locally advanced rectal cancer
por: Craven, I, et al.
Publicado: (2007)

Prostate Stereotactic Ablative Radiation Therapy Using Volumetric Modulated Arc Therapy to Dominant Intraprostatic Lesions()
por: Murray, Louise J., et al.
Publicado: (2014)

Developing a class solution for Prostate Stereotactic Ablative Body Radiotherapy (SABR) using Volumetric Modulated Arc Therapy (VMAT)
por: Murray, Louise J., et al.
Publicado: (2014)

NEOSCOPE: A randomised phase II study of induction chemotherapy followed by oxaliplatin/capecitabine or carboplatin/paclitaxel based pre-operative chemoradiation for resectable oesophageal adenocarcinoma
por: Mukherjee, Somnath, et al.
Publicado: (2017)

SPARC's Initiative
por: Alison Buckholtz
Publicado: (2002)

Evolution of dental tissue mineralization: an analysis of the jawed vertebrate SPARC and SPARC-L families
por: Enault, Sébastien, et al.
Publicado: (2018)

Mediated effect of cognitive behavioural therapy on depression outcomes
por: Odondi, Lang'o, et al.
Publicado: (2013)

Divergent Expression of SPARC, SPARC-L, and SCPP Genes During Jawed Vertebrate Cartilage Mineralization
por: Romero, Adrian, et al.
Publicado: (2021)

Llamadme Stalin : la historia secreta de un revolucionario /
por: Sebag Montefiore, Simon, 1965-
Publicado: (2008)

Escrito en la historia : cartas que cambiaron el mundo /
por: Sebag Montefiore, Simon, 1965-
Publicado: (2019)

NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinoma
por: Mukherjee, Somnath, et al.
Publicado: (2015)

Considerations for the treatment of pancreatic cancer during the COVID-19 pandemic: the UK consensus position
por: Jones, Christopher M., et al.
Publicado: (2020)

Reply to Comment on “The UK consensus position on the treatment of pancreatic cancer during the COVID-19 pandemic”
por: Jones, Christopher M., et al.
Publicado: (2020)

Speech Entrainment for Aphasia Recovery (SpARc) phase II trial design
por: Cassarly, Christy, et al.
Publicado: (2021)

A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR)
por: O’Cathail, Séan M., et al.
Publicado: (2020)

Lung Stereotactic Body Radiotherapy (SBRT) Using Spot-Scanning Proton Arc (SPArc) Therapy: A Feasibility Study
por: Liu, Gang, et al.
Publicado: (2021)

ARCII: A phase II trial of the HIV protease inhibitor Nelfinavir in combination with chemoradiation for locally advanced inoperable pancreatic cancer
por: Wilson, James M., et al.
Publicado: (2016)

Opportunity cost--a neglected aspect of cancer treatment.
por: Munro, A. J., et al.
Publicado: (1992)

SPARC functions as an inhibitor of adipogenesis
por: Nie, Jing, et al.
Publicado: (2009)

SPARC–Dependent Cardiomyopathy in Drosophila
por: Hartley, Paul S., et al.
Publicado: (2016)

Study protocol: a cluster-randomized trial implementing Sustained Patient-centered Alcohol-related Care (SPARC trial)
por: Glass, Joseph E., et al.
Publicado: (2018)

The SABRTooth feasibility trial protocol: a study to determine the feasibility and acceptability of conducting a phase III randomised controlled trial comparing stereotactic ablative radiotherapy (SABR) with surgery in patients with peripheral stage I non-small cell lung cancer (NSCLC) considered to be at higher risk of complications from surgical resection
por: Snee, M. P., et al.
Publicado: (2016)

Supporting Practices to Adopt Registry-Based Care (SPARC): protocol for a randomized controlled trial
por: Etz, Rebecca S, et al.
Publicado: (2015)

Erratum to: The SABRTooth feasibility trial protocol: a study to determine the feasibility and acceptability of conducting a phase III randomised controlled trial comparing stereotactic ablative radiotherapy (SABR) with surgery in patients with peripheral stage I non-small cell lung cancer (NSCLC) considered to be at higher risk of complications from surgical resection
por: Snee, M. P., et al.
Publicado: (2016)

Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I)
por: Northover, J, et al.
Publicado: (2010)

Biomarkers in anal cancer: from biological understanding to stratified treatment
por: Jones, Christopher M, et al.
Publicado: (2017)

Assessment of biological dosimetric margin for stereotactic body radiation therapy
por: Kawahara, Daisuke, et al.
Publicado: (2020)

Employing knowledge translation interventions to increase the use of therapeutic hypothermia post arrest: the SPARC Network Trial
por: Morrison, LJ, et al.
Publicado: (2011)

Practice-changing radiation therapy trials for the treatment of cancer: where are we 150 years after the birth of Marie Curie?
por: Thompson, Mareike K., et al.
Publicado: (2018)

The Function of SPARC as a Mediator of Fibrosis
por: Trombetta-eSilva, Jessica, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4aur4kp80365elb8gsa0n5nfri