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Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8(+) T cells during vaccine immunotherapy

BACKGROUND: Dendritic cells (DCs) mount tumor-associated antigens (TAAs), and the double-stranded RNA adjuvant Poly(I:C) stimulates Toll-like receptor 3 (TLR3) signal in DC, which in turn induces type I interferon (IFN) and interleukin-12 (IL-12), then cross-primes cytotoxic T lymphocytes (CTLs). Pr...

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Detalles Bibliográficos
Autores principales:	Takeda, Yohei, Azuma, Masahiro, Matsumoto, Misako, Seya, Tsukasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020536/ https://www.ncbi.nlm.nih.gov/pubmed/27619885 http://dx.doi.org/10.1186/s13046-016-0416-x

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