A lack of peptide binding and decreased thermostability suggests that the CASKIN2 scaffolding protein SH3 domain may be vestigial

BACKGROUND: CASKIN2 is a neuronal signaling scaffolding protein comprised of multiple ankyrin repeats, two SAM domains, and one SH3 domain. The CASKIN2 SH3 domain for an NMR structural determination because its peptide-binding cleft appeared to deviate from the repertoire of aromatic enriched amino...

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Detalles Bibliográficos
Autores principales: Kwan, Jamie J., Donaldson, Logan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020537/
https://www.ncbi.nlm.nih.gov/pubmed/27619958
http://dx.doi.org/10.1186/s12900-016-0065-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020537/
https://www.ncbi.nlm.nih.gov/pubmed/27619958
http://dx.doi.org/10.1186/s12900-016-0065-5

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