Cargando…

Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site

Here we demonstrate that conditional deletion of mouse uterine Trp53 (p53(d/d)), molecularly linked to mTORC1 activation and causally linked to premature uterine senescence and preterm birth, results in aberrant lipid signatures within the heterogeneous cell types of embryo implantation sites on day...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lanekoff, Ingela, Cha, Jeeyeon, Kyle, Jennifer E., Dey, Sudhansu K., Laskin, Julia, Burnum-Johnson, Kristin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020559/ https://www.ncbi.nlm.nih.gov/pubmed/27620843 http://dx.doi.org/10.1038/srep33023

Ejemplares similares

Author Correction: In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
por: Duncan, Kyle D., et al.
Publicado: (2021)

In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases
por: Duncan, Kyle D., et al.
Publicado: (2021)

Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation
por: Yuan, Jia, et al.
Publicado: (2018)

Loss of Cannabinoid Receptor CB1 Induces Preterm Birth
por: Wang, Haibin, et al.
Publicado: (2008)

Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos
por: Chandrakanthan, Vashe, et al.
Publicado: (2006)

CpG preconditioning reduces accumulation of lysophosphatidylcholine in ischemic brain tissue after middle cerebral artery occlusion
por: Mavroudakis, Leonidas, et al.
Publicado: (2020)

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice
por: Krais, Annette M., et al.
Publicado: (2015)

Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity
por: van der Weyden, L, et al.
Publicado: (2013)

Candidate gene linkage approach to Identify DNA variants that predispose to preterm birth
por: Bream, Elise N.A., et al.
Publicado: (2012)

Host–Guest Chemistry for Simultaneous Imaging of Endogenous Alkali Metals and Metabolites with Mass Spectrometry
por: Mavroudakis, Leonidas, et al.
Publicado: (2022)

Ion-to-Image, i2i, a Mass Spectrometry Imaging Data Analysis Platform for Continuous Ionization Techniques
por: Lillja, Johan, et al.
Publicado: (2023)

Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?
por: McAllister, Kimberly A, et al.
Publicado: (2002)

Analysis of intact ladderane phospholipids, originating from viable anammox bacteria, using RP-LC-ESI-MS
por: Lanekoff, Ingela, et al.
Publicado: (2010)

Quantitative determination of sn-positional phospholipid isomers in MS(n) using silver cationization
por: Lillja, Johan, et al.
Publicado: (2022)

Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System
por: Mavroudakis, Leonidas, et al.
Publicado: (2023)

Surface sampling capillary electrophoresis–mass spectrometry for a direct chemical characterization of tissue and blood samples
por: Golubova, Anastasia, et al.
Publicado: (2022)

Identification and Imaging of Prostaglandin Isomers Utilizing MS(3) Product Ions and Silver Cationization
por: Mavroudakis, Leonidas, et al.
Publicado: (2023)

Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion
por: Beauchamp, Marie-Claude, et al.
Publicado: (2022)

A Direct Infusion Probe for Rapid Metabolomics of Low-Volume Samples
por: Marques, Cátia, et al.
Publicado: (2022)

Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS
por: Cardoso-Palacios, Carlos, et al.
Publicado: (2016)

The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells
por: Ishii, Kei, et al.
Publicado: (2014)

Entosis Allows Timely Elimination of the Luminal Epithelial Barrier for Embryo Implantation
por: Li, Yingju, et al.
Publicado: (2015)

p53 Regulation by TRP2 Is Not Pervasive in Melanoma
por: Houben, Roland, et al.
Publicado: (2014)

Maintenance of pluripotency in mouse ES cells without Trp53
por: Shigeta, Masaki, et al.
Publicado: (2013)

Differential Effects of Trp53 Alterations in Murine Colorectal Cancer
por: Betzler, Alexander M., et al.
Publicado: (2021)

Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53
por: Palanichamy, Jayanth Kumar, et al.
Publicado: (2023)

Crohn’s Disease Localization Displays Different Predisposing Genetic Variants
por: Palmieri, Orazio, et al.
Publicado: (2017)

Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice
por: Branca, Jane A, et al.
Publicado: (2020)

RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis
por: Gomes, Anielle L., et al.
Publicado: (2020)

Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N-Trp53(tm1Hw1) with TALEN-mediated Trp53 mutant gene
por: Yun, Woobin, et al.
Publicado: (2023)

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/− with susceptibility versus C57BL/6-Trp53+/− mice with resistance to mammary tumors
por: Böhringer, M, et al.
Publicado: (2013)

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases
por: Zhang, Yun, et al.
Publicado: (2018)

Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in Trp53+/- mice
por: Blackburn, AC, et al.
Publicado: (2012)

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes
por: Haley, Victoria L, et al.
Publicado: (2012)

Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice
por: Yue, Yangbo, et al.
Publicado: (2016)

Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53
por: Mainz, Laura, et al.
Publicado: (2022)

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice
por: Rose Li, Yun, et al.
Publicado: (2020)

Progesterone and preterm birth
por: Norman, Jane E.
Publicado: (2020)

Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts
por: Chandrakanthan, Vashe, et al.
Publicado: (2007)

Role of JNK in a Trp53-Dependent Mouse Model of Breast Cancer
por: Cellurale, Cristina, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_49tjpjk2o68aqqsbdk3moah3er