Cellular response to alkylating agent MNNG is impaired in STAT1‐deficients cells

The S(N)1 alkylating agents activate the mismatch repair system leading to delayed G(2)/M cell cycle arrest and DNA repair with subsequent survival or cell death. STAT1, an anti‐proliferative and pro‐apoptotic transcription factor is known to potentiate p53 and to affect DNA‐damage cellular response...

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Detalles Bibliográficos
Autores principales: Ah‐Koon, Laurent, Lesage, Denis, Lemadre, Elodie, Souissi, Inès, Fagard, Remi, Varin‐Blank, Nadine, Fabre, Emmanuelle E., Schischmanoff, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020624/
https://www.ncbi.nlm.nih.gov/pubmed/27464833
http://dx.doi.org/10.1111/jcmm.12887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020624/
https://www.ncbi.nlm.nih.gov/pubmed/27464833
http://dx.doi.org/10.1111/jcmm.12887

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