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Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling
The mechanistic Target Of Rapamycin Complex 1 (mTORC1) is central to the cellular response to changes in nutrient signals such as amino acids. CASTOR1 is shown to be an arginine sensor, which plays an important role in the activation of the mTORC1 pathway. In the deficiency of arginine, CASTOR1 inte...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020642/ https://www.ncbi.nlm.nih.gov/pubmed/27648300 http://dx.doi.org/10.1038/celldisc.2016.35 |