Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice

Calcific aortic valve disease (CAVD) is the most common cause of aortic stenosis. Currently, there is no non-invasive medical therapy for CAVD. Matrix metalloproteinases (MMPs) are upregulated in CAVD and play a role in its pathogenesis. Here, we evaluated the effect of doxycycline, a nonselective M...

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Detalles Bibliográficos
Autores principales: Jung, Jae-Joon, Razavian, Mahmoud, Kim, Hye-Yeong, Ye, Yunpeng, Golestani, Reza, Toczek, Jakub, Zhang, Jiasheng, Sadeghi, Mehran M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020643/
https://www.ncbi.nlm.nih.gov/pubmed/27619752
http://dx.doi.org/10.1038/srep32659

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