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Characterization of a knock-in mouse model of the homozygous p.V37I variant in Gjb2
The homozygous p.V37I variant in GJB2 is prevalent in East and Southeast Asians and may lead to mild-to-moderate hearing loss with reduced penetrance. To investigate the pathogenic mechanism underlying this variant, we generated a knock-in mouse model of homozygous p.V37I by an embryonic stem cell g...
Autores principales: | Chen, Ying, Hu, Lingxiang, Wang, Xueling, Sun, Changling, Lin, Xin, li, Lei, Mei, Ling, Huang, Zhiwu, Yang, Tao, Wu, Hao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020688/ https://www.ncbi.nlm.nih.gov/pubmed/27623246 http://dx.doi.org/10.1038/srep33279 |
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