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Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS

OBJECTIVES: A recent individual patient data (IPD) meta-analysis suggested that patients with moderate or severe acute respiratory distress syndrome (ARDS) benefit from higher positive end-expiratory pressure (PEEP) ventilation strategies. However, thresholds for continuous variables (eg, hypoxaemia...

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Detalles Bibliográficos
Autores principales:	Kasenda, Benjamin, Sauerbrei, Willi, Royston, Patrick, Mercat, Alain, Slutsky, Arthur S, Cook, Deborah, Guyatt, Gordon H, Brochard, Laurent, Richard, Jean-Christophe M, Stewart, Thomas E, Meade, Maureen, Briel, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Intensive Care
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020750/ https://www.ncbi.nlm.nih.gov/pubmed/27609843 http://dx.doi.org/10.1136/bmjopen-2016-011148

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