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Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study

OBJECTIVES: Various studies have revealed a close association between sedentary behaviour and metabolic diseases, yet the association between sedentary time and non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, we investigated the association between sitting time and NAFLD in...

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Autores principales: Wei, Huili, Qu, Hua, Wang, Hang, Deng, Huacong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020753/
https://www.ncbi.nlm.nih.gov/pubmed/27609847
http://dx.doi.org/10.1136/bmjopen-2016-011939
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author Wei, Huili
Qu, Hua
Wang, Hang
Deng, Huacong
author_facet Wei, Huili
Qu, Hua
Wang, Hang
Deng, Huacong
author_sort Wei, Huili
collection PubMed
description OBJECTIVES: Various studies have revealed a close association between sedentary behaviour and metabolic diseases, yet the association between sedentary time and non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, we investigated the association between sitting time and NAFLD in a Chinese male population and explored its underlying mechanism. STUDY DESIGN: A cross-sectional study. SETTING: Chongqing, China. PARTICIPANTS: Our study included 2054 male participants; all of the participants were of Han nationality. PRIMARY OUTCOME MEASURES: Sitting time was assessed using a self-reported questionnaire concerning the time devoted to sitting behaviour. Various clinical and demographic biomarkers were measured. Logistic regression analyses were used to investigate the ORs and the 95% CIs between sitting time and NAFLD. RESULTS: We found a higher proportion of NAFLD across the tertiles of sitting time (p trend=0.003). Multivariate linear regression analyses showed sitting time independently correlated with homoeostasis model assessment for insulin resistance (HOMA-IR), alanine aminotransferase, γ-glutamyl transpeptidase, body mass index, triglyceride and the high-sensitive C reactive protein (hsCRP) (all p<0.05). Further logistic regression analyses showed that longer sitting time (>7.1 hours/day) was associated with a higher prevalence of NAFLD (OR 1.09; 95% CI (1.04 to 1.67)) after adjusting for confounders. However, this association was insignificant after further adjusting for hsCRP (OR 1.03; 95% CI (0.92 to 1.84)). CONCLUSIONS: Sitting time was positively associated with the prevalence of NAFLD, and this association might be affected by inflammation.
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spelling pubmed-50207532016-09-20 Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study Wei, Huili Qu, Hua Wang, Hang Deng, Huacong BMJ Open Public Health OBJECTIVES: Various studies have revealed a close association between sedentary behaviour and metabolic diseases, yet the association between sedentary time and non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, we investigated the association between sitting time and NAFLD in a Chinese male population and explored its underlying mechanism. STUDY DESIGN: A cross-sectional study. SETTING: Chongqing, China. PARTICIPANTS: Our study included 2054 male participants; all of the participants were of Han nationality. PRIMARY OUTCOME MEASURES: Sitting time was assessed using a self-reported questionnaire concerning the time devoted to sitting behaviour. Various clinical and demographic biomarkers were measured. Logistic regression analyses were used to investigate the ORs and the 95% CIs between sitting time and NAFLD. RESULTS: We found a higher proportion of NAFLD across the tertiles of sitting time (p trend=0.003). Multivariate linear regression analyses showed sitting time independently correlated with homoeostasis model assessment for insulin resistance (HOMA-IR), alanine aminotransferase, γ-glutamyl transpeptidase, body mass index, triglyceride and the high-sensitive C reactive protein (hsCRP) (all p<0.05). Further logistic regression analyses showed that longer sitting time (>7.1 hours/day) was associated with a higher prevalence of NAFLD (OR 1.09; 95% CI (1.04 to 1.67)) after adjusting for confounders. However, this association was insignificant after further adjusting for hsCRP (OR 1.03; 95% CI (0.92 to 1.84)). CONCLUSIONS: Sitting time was positively associated with the prevalence of NAFLD, and this association might be affected by inflammation. BMJ Publishing Group 2016-09-08 /pmc/articles/PMC5020753/ /pubmed/27609847 http://dx.doi.org/10.1136/bmjopen-2016-011939 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Public Health
Wei, Huili
Qu, Hua
Wang, Hang
Deng, Huacong
Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study
title Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study
title_full Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study
title_fullStr Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study
title_full_unstemmed Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study
title_short Associations between sitting time and non-alcoholic fatty liver diseases in Chinese male workers: a cross-sectional study
title_sort associations between sitting time and non-alcoholic fatty liver diseases in chinese male workers: a cross-sectional study
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020753/
https://www.ncbi.nlm.nih.gov/pubmed/27609847
http://dx.doi.org/10.1136/bmjopen-2016-011939
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