Palladium‐Catalyzed Oxidative Synthesis of α‐Acetoxylated Enones from Alkynes

We report a palladium‐catalyzed oxidative functionalization of alkynes to generate α‐acetoxylated enones in one step. A range of functional groups are well‐tolerated in this reaction. Mechanistic studies, including the use of (18)O‐labeled DMSO, revealed that the ketone oxygen atom in the product or...

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Detalles Bibliográficos
Autores principales: Jiang, Tuo, Quan, Xu, Zhu, Can, Andersson, Pher G., Bäckvall, Jan‐E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021131/
https://www.ncbi.nlm.nih.gov/pubmed/27060476
http://dx.doi.org/10.1002/anie.201600696
Descripción
Sumario:We report a palladium‐catalyzed oxidative functionalization of alkynes to generate α‐acetoxylated enones in one step. A range of functional groups are well‐tolerated in this reaction. Mechanistic studies, including the use of (18)O‐labeled DMSO, revealed that the ketone oxygen atom in the product originates from DMSO.

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