Application of the TGx‐28.65 transcriptomic biomarker to classify genotoxic and non‐genotoxic chemicals in human TK6 cells in the presence of rat liver S9

In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx‐28.65) for classifying agents as genotoxic (DNA damaging) and non‐genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not expr...

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Detalles Bibliográficos
Autores principales: Yauk, Carole L., Buick, Julie K., Williams, Andrew, Swartz, Carol D., Recio, Leslie, Li, Heng‐Hong, Fornace, Albert J., Thomson, Errol M., Aubrecht, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021161/
https://www.ncbi.nlm.nih.gov/pubmed/26946220
http://dx.doi.org/10.1002/em.22004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021161/
https://www.ncbi.nlm.nih.gov/pubmed/26946220
http://dx.doi.org/10.1002/em.22004

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