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Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy. Here we define the role of the most abundant cell type in the brain, the astrocyte, in promoting brain metastasis. Breast and lung cancer cells exp...

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Detalles Bibliográficos
Autores principales:	Chen, Qing, Boire, Adrienne, Jin, Xin, Valiente, Manuel, Er, Ekrem Emrah, Lopez-Soto, Alejandro, Jacob, Leni, Patwa, Ruzeen, Shah, Hardik, Xu, Ke, Cross, Justin R., Massagué, Joan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021195/ https://www.ncbi.nlm.nih.gov/pubmed/27225120 http://dx.doi.org/10.1038/nature18268

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