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Natural Killer Cell Diversity in Viral Infection: Why and How Much?
Natural killer cells are a diverse group of innate lymphocytes that are specialized to rapidly respond to cancerous or virus-infected cells. NK cell function is controlled by the integration of signals from activating and inhibitory receptors expressed at the cell surface. Variegated expression patt...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Pathogens and Immunity
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021221/ https://www.ncbi.nlm.nih.gov/pubmed/27635417 http://dx.doi.org/10.20411/pai.v1i1.142 |
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author | Blish, Catherine A. |
author_facet | Blish, Catherine A. |
author_sort | Blish, Catherine A. |
collection | PubMed |
description | Natural killer cells are a diverse group of innate lymphocytes that are specialized to rapidly respond to cancerous or virus-infected cells. NK cell function is controlled by the integration of signals from activating and inhibitory receptors expressed at the cell surface. Variegated expression patterns of these activating and inhibitory receptors at the single cell level leads to a highly diverse NK cell repertoire. Here I review the factors that influence NK cell repertoire diversity and its functional consequences for our ability to fight viruses. |
format | Online Article Text |
id | pubmed-5021221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Pathogens and Immunity |
record_format | MEDLINE/PubMed |
spelling | pubmed-50212212016-09-13 Natural Killer Cell Diversity in Viral Infection: Why and How Much? Blish, Catherine A. Pathog Immun Review Natural killer cells are a diverse group of innate lymphocytes that are specialized to rapidly respond to cancerous or virus-infected cells. NK cell function is controlled by the integration of signals from activating and inhibitory receptors expressed at the cell surface. Variegated expression patterns of these activating and inhibitory receptors at the single cell level leads to a highly diverse NK cell repertoire. Here I review the factors that influence NK cell repertoire diversity and its functional consequences for our ability to fight viruses. Pathogens and Immunity 2016-08-31 /pmc/articles/PMC5021221/ /pubmed/27635417 http://dx.doi.org/10.20411/pai.v1i1.142 Text en © Pathogens and Immunity 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Review Blish, Catherine A. Natural Killer Cell Diversity in Viral Infection: Why and How Much? |
title | Natural Killer Cell Diversity in Viral Infection: Why and How Much? |
title_full | Natural Killer Cell Diversity in Viral Infection: Why and How Much? |
title_fullStr | Natural Killer Cell Diversity in Viral Infection: Why and How Much? |
title_full_unstemmed | Natural Killer Cell Diversity in Viral Infection: Why and How Much? |
title_short | Natural Killer Cell Diversity in Viral Infection: Why and How Much? |
title_sort | natural killer cell diversity in viral infection: why and how much? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021221/ https://www.ncbi.nlm.nih.gov/pubmed/27635417 http://dx.doi.org/10.20411/pai.v1i1.142 |
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