Cargando…

Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1α and NF-κB-dependent mechanisms

Dexamethasone is a synthetic glucocorticoid frequently used to suppress side-effects of anticancer chemotherapy. In the present study, we showed that dexamethasone treatment leads to concentration-dependent downregulation of cancer-associated marker, carbonic anhydrase IX (CA IX), at the level of pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simko, Veronika, Takacova, Martina, Debreova, Michaela, Laposova, Katarina, Ondriskova-Panisova, Elena, Pastorekova, Silvia, Csaderova, Lucia, Pastorek, Jaromir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021256/ https://www.ncbi.nlm.nih.gov/pubmed/27431580 http://dx.doi.org/10.3892/ijo.2016.3621

Ejemplares similares

Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts
por: Ditte, Zuzana, et al.
Publicado: (2014)

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors
por: Sedlakova, Olga, et al.
Publicado: (2014)

Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells
por: Kajanova, Ivana, et al.
Publicado: (2020)

The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration
por: Csaderova, Lucia, et al.
Publicado: (2013)

Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX
por: Zatovicova, Miriam, et al.
Publicado: (2022)

Hypoxic marker CA IX and adhesion mediator β-catenin are downregulated by lymphocytic choriomeningitis virus persistent infection
por: Fabianova, Andrea, et al.
Publicado: (2018)

Carbonic anhydrase IX in oligodendroglial brain tumors
por: Järvelä, Sally, et al.
Publicado: (2008)

Hypoxia Marker Carbonic Anhydrase IX Is Present in Abdominal Aortic Aneurysm Tissue and Plasma
por: Grossmannova, Katarina, et al.
Publicado: (2022)

Impairment of Hypoxia-Induced CA IX by Beta-Blocker Propranolol—Impact on Progression and Metastatic Potential of Colorectal Cancer Cells
por: Barathova, Monika, et al.
Publicado: (2020)

Hypoxia induces cancer-associated cAMP/PKA signalling through HIF-mediated transcriptional control of adenylyl cyclases VI and VII
por: Simko, Veronika, et al.
Publicado: (2017)

Expression of carbonic anhydrases IX and XII during mouse embryonic development
por: Kallio, Heini, et al.
Publicado: (2006)

Lactate stimulates CA IX expression in normoxic cancer cells
por: Panisova, Elena, et al.
Publicado: (2017)

Propranolol, Promising Chemosensitizer and Candidate for the Combined Therapy through Disruption of Tumor Microenvironment Homeostasis by Decreasing the Level of Carbonic Anhydrase IX
por: Puzderova, Barbora, et al.
Publicado: (2023)

Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype
por: Barathova, M, et al.
Publicado: (2008)

Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas
por: Viikilä, Pia, et al.
Publicado: (2016)

Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs
por: Hynninen, Piritta, et al.
Publicado: (2004)

Carbonic Anhydrase IX—Mouse versus Human
por: Takacova, Martina, et al.
Publicado: (2019)

Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy
por: Vidlickova, Ivana, et al.
Publicado: (2016)

ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non-redundantly to ADAM17
por: Zatovicova, Miriam, et al.
Publicado: (2022)

Carbonic Anhydrase IX in Tumor Tissue and Plasma of Breast Cancer Patients: Reliable Biomarker of Hypoxia and Prognosis
por: Rezuchova, Ingeborg, et al.
Publicado: (2023)

Clinical and Pre-Clinical Evidence of Carbonic Anhydrase IX in Pancreatic Cancer and Its High Expression in Pre-Cancerous Lesions
por: Strapcova, Sabina, et al.
Publicado: (2020)

Understanding metabolic alterations and heterogeneity in cancer progression through validated immunodetection of key molecular components: a case of carbonic anhydrase IX
por: Takacova, Martina, et al.
Publicado: (2022)

The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis
por: Nordfors, Kristiina, et al.
Publicado: (2010)

Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors
por: Kalavska, Katarina, et al.
Publicado: (2017)

Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
por: Zatovicova, M, et al.
Publicado: (2005)

Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients
por: Kalavska, Katarina, et al.
Publicado: (2016)

The role of carbonic anhydrase IX in cancer development: links to hypoxia, acidosis, and beyond
por: Pastorekova, Silvia, et al.
Publicado: (2019)

PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity
por: Simko, Veronika, et al.
Publicado: (2020)

The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells
por: Ames, Samantha, et al.
Publicado: (2018)

Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy
por: PASTOREK, MICHAL, et al.
Publicado: (2015)

Downregulation of Carbonic Anhydrase IX Promotes Col10a1 Expression in Chondrocytes
por: Maruyama, Toshifumi, et al.
Publicado: (2013)

Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX
por: Koruza, Katarina, et al.
Publicado: (2020)

Sulforaphane-induced apoptosis involves the type 1 IP(3) receptor
por: Hudecova, Sona, et al.
Publicado: (2016)

Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance
por: Gibadulinova, Adriana, et al.
Publicado: (2016)

Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors
por: Liskova, Veronika, et al.
Publicado: (2019)

Anti-chondroitin sulfate proteoglycan 4-specific antibodies modify the effects of vemurafenib on melanoma cells differentially in normoxia and hypoxia
por: PUCCIARELLI, DANIELA, et al.
Publicado: (2015)

CAIX Regulates Invadopodia Formation through Both a pH-Dependent Mechanism and Interplay with Actin Regulatory Proteins
por: Debreova, Michaela, et al.
Publicado: (2019)

Targeting Carbonic Anhydrase IX Activity and Expression
por: Mahon, Brian P., et al.
Publicado: (2015)

Carbonic anhydrase IX and acid transport in cancer
por: Becker, Holger M.
Publicado: (2019)

Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
por: Hussain, S A, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_mg2gg5l1hjs3eijbob3c236elf