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Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors

Deficiency of mitochondrial complex I is encountered in both rare and common diseases, but we have limited therapeutic options to treat this lesion to the oxidative phosphorylation system (OXPHOS). Idebenone and menadione are redox-active molecules capable of rescuing OXPHOS activity by engaging com...

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Detalles Bibliográficos
Autores principales:	Vafai, Scott B., Mevers, Emily, Higgins, Kathleen W., Fomina, Yevgenia, Zhang, Jianming, Mandinova, Anna, Newman, David, Shaw, Stanley Y., Clardy, Jon, Mootha, Vamsi K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021346/ https://www.ncbi.nlm.nih.gov/pubmed/27622560 http://dx.doi.org/10.1371/journal.pone.0162686

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