Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand

Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the d...

Descripción completa

Detalles Bibliográficos
Autores principales: Greene, Maxwell, Lai, Yongjie, Pajcini, Kostandin, Bailis, Will, Pear, Warren S., Lancaster, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021350/
https://www.ncbi.nlm.nih.gov/pubmed/27622512
http://dx.doi.org/10.1371/journal.pone.0161157
_version_ 1782453338387775488
author Greene, Maxwell
Lai, Yongjie
Pajcini, Kostandin
Bailis, Will
Pear, Warren S.
Lancaster, Eric
author_facet Greene, Maxwell
Lai, Yongjie
Pajcini, Kostandin
Bailis, Will
Pear, Warren S.
Lancaster, Eric
author_sort Greene, Maxwell
collection PubMed
description Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.
format Online
Article
Text
id pubmed-5021350
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-50213502016-09-27 Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand Greene, Maxwell Lai, Yongjie Pajcini, Kostandin Bailis, Will Pear, Warren S. Lancaster, Eric PLoS One Research Article Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown. Public Library of Science 2016-09-13 /pmc/articles/PMC5021350/ /pubmed/27622512 http://dx.doi.org/10.1371/journal.pone.0161157 Text en © 2016 Greene et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Greene, Maxwell
Lai, Yongjie
Pajcini, Kostandin
Bailis, Will
Pear, Warren S.
Lancaster, Eric
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_full Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_fullStr Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_full_unstemmed Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_short Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
title_sort delta/notch-like egf-related receptor (dner) is not a notch ligand
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021350/
https://www.ncbi.nlm.nih.gov/pubmed/27622512
http://dx.doi.org/10.1371/journal.pone.0161157
work_keys_str_mv AT greenemaxwell deltanotchlikeegfrelatedreceptordnerisnotanotchligand
AT laiyongjie deltanotchlikeegfrelatedreceptordnerisnotanotchligand
AT pajcinikostandin deltanotchlikeegfrelatedreceptordnerisnotanotchligand
AT bailiswill deltanotchlikeegfrelatedreceptordnerisnotanotchligand
AT pearwarrens deltanotchlikeegfrelatedreceptordnerisnotanotchligand
AT lancastereric deltanotchlikeegfrelatedreceptordnerisnotanotchligand

Ejemplares similares