CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum

Visceral leishmaniasis (VL) is a serious and fatal disease. Therapeutic drugs are toxic and non-sterilizing. The etiological agents Leishmania infantum and Leishmania donovani cause active and asymptomatic diseases. Effective drugs to treat VL exist but unfortunately, post-treatment relapses are com...

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Autores principales: Lopes, Carolina S., Daifalla, Nada, Das, Bikul, Dias da Silva, Valdo, Campos-Neto, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021359/
https://www.ncbi.nlm.nih.gov/pubmed/27622907
http://dx.doi.org/10.1371/journal.pone.0162927
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author Lopes, Carolina S.
Daifalla, Nada
Das, Bikul
Dias da Silva, Valdo
Campos-Neto, Antonio
author_facet Lopes, Carolina S.
Daifalla, Nada
Das, Bikul
Dias da Silva, Valdo
Campos-Neto, Antonio
author_sort Lopes, Carolina S.
collection PubMed
description Visceral leishmaniasis (VL) is a serious and fatal disease. Therapeutic drugs are toxic and non-sterilizing. The etiological agents Leishmania infantum and Leishmania donovani cause active and asymptomatic diseases. Effective drugs to treat VL exist but unfortunately, post-treatment relapses are common. Little is known why drugs are non-sterilizing or how these intracellular pathogens can escape treatment. Here, using a murine model of VL we found that CD271+/Sca1+ bone marrow mesenchymal stem cells (BM-MSCs) are readily infected in vitro and in vivo by L. infantum. Because BM-MSCs express potent drug efflux pumps, e.g., ABCG2 it is possible that this unique intracellular infectious niche could allow L. infantum to escape anti-parasite drugs.
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spelling pubmed-50213592016-09-27 CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum Lopes, Carolina S. Daifalla, Nada Das, Bikul Dias da Silva, Valdo Campos-Neto, Antonio PLoS One Research Article Visceral leishmaniasis (VL) is a serious and fatal disease. Therapeutic drugs are toxic and non-sterilizing. The etiological agents Leishmania infantum and Leishmania donovani cause active and asymptomatic diseases. Effective drugs to treat VL exist but unfortunately, post-treatment relapses are common. Little is known why drugs are non-sterilizing or how these intracellular pathogens can escape treatment. Here, using a murine model of VL we found that CD271+/Sca1+ bone marrow mesenchymal stem cells (BM-MSCs) are readily infected in vitro and in vivo by L. infantum. Because BM-MSCs express potent drug efflux pumps, e.g., ABCG2 it is possible that this unique intracellular infectious niche could allow L. infantum to escape anti-parasite drugs. Public Library of Science 2016-09-13 /pmc/articles/PMC5021359/ /pubmed/27622907 http://dx.doi.org/10.1371/journal.pone.0162927 Text en © 2016 Lopes et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lopes, Carolina S.
Daifalla, Nada
Das, Bikul
Dias da Silva, Valdo
Campos-Neto, Antonio
CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum
title CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum
title_full CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum
title_fullStr CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum
title_full_unstemmed CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum
title_short CD271+ Mesenchymal Stem Cells as a Possible Infectious Niche for Leishmania infantum
title_sort cd271+ mesenchymal stem cells as a possible infectious niche for leishmania infantum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021359/
https://www.ncbi.nlm.nih.gov/pubmed/27622907
http://dx.doi.org/10.1371/journal.pone.0162927
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