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Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity

An effective preventive vaccine is highly sought after in order to stem the current HIV-1 pandemic. Both conservation of contiguous gp41 membrane-proximal external region (MPER) amino acid sequences across HIV-1 clades and the ability of anti-MPER broadly neutralizing antibodies (BNAbs) to block vir...

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Detalles Bibliográficos
Autores principales:	Donius, Luke R., Cheng, Yuxing, Choi, Jaewon, Sun, Zhen-Yu J., Hanson, Melissa, Zhang, Michael, Gierahn, Todd M., Marquez, Susanna, Uduman, Mohammed, Kleinstein, Steven H., Irvine, Darrell, Love, J. Christopher, Reinherz, Ellis L., Kim, Mikyung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021391/ https://www.ncbi.nlm.nih.gov/pubmed/27466419 http://dx.doi.org/10.1128/JVI.01089-16

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