Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy

Q fever is a zoonotic bacterial disease caused by Coxiella burnetii. Tumor necrosis factor-alpha (TNF-α) plays a pivotal role in the defense against infection with this Gram-negative coccobacillus. Theoretically, patients who are treated with anti-TNF-α medications are at risk for developing chronic...

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Autores principales: Hirsch, Julianna, Astrahan, Anna, Odeh, Majed, Elias, Nizar, Rosner, Itzhak, Rimar, Doron, Kaly, Lisa, Rozenbaum, Michael, Boulman, Nina, Slobodin, Gleb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021454/
https://www.ncbi.nlm.nih.gov/pubmed/27656302
http://dx.doi.org/10.1155/2016/4586150
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author Hirsch, Julianna
Astrahan, Anna
Odeh, Majed
Elias, Nizar
Rosner, Itzhak
Rimar, Doron
Kaly, Lisa
Rozenbaum, Michael
Boulman, Nina
Slobodin, Gleb
author_facet Hirsch, Julianna
Astrahan, Anna
Odeh, Majed
Elias, Nizar
Rosner, Itzhak
Rimar, Doron
Kaly, Lisa
Rozenbaum, Michael
Boulman, Nina
Slobodin, Gleb
author_sort Hirsch, Julianna
collection PubMed
description Q fever is a zoonotic bacterial disease caused by Coxiella burnetii. Tumor necrosis factor-alpha (TNF-α) plays a pivotal role in the defense against infection with this Gram-negative coccobacillus. Theoretically, patients who are treated with anti-TNF-α medications are at risk for developing chronic Q fever. We present two patients who developed Q fever while being treated with anti-TNF-α agents and discuss the significance of timely diagnosis of C. burnetii infection in these patients.
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spelling pubmed-50214542016-09-21 Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy Hirsch, Julianna Astrahan, Anna Odeh, Majed Elias, Nizar Rosner, Itzhak Rimar, Doron Kaly, Lisa Rozenbaum, Michael Boulman, Nina Slobodin, Gleb Case Rep Infect Dis Case Report Q fever is a zoonotic bacterial disease caused by Coxiella burnetii. Tumor necrosis factor-alpha (TNF-α) plays a pivotal role in the defense against infection with this Gram-negative coccobacillus. Theoretically, patients who are treated with anti-TNF-α medications are at risk for developing chronic Q fever. We present two patients who developed Q fever while being treated with anti-TNF-α agents and discuss the significance of timely diagnosis of C. burnetii infection in these patients. Hindawi Publishing Corporation 2016 2016-08-30 /pmc/articles/PMC5021454/ /pubmed/27656302 http://dx.doi.org/10.1155/2016/4586150 Text en Copyright © 2016 Julianna Hirsch et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hirsch, Julianna
Astrahan, Anna
Odeh, Majed
Elias, Nizar
Rosner, Itzhak
Rimar, Doron
Kaly, Lisa
Rozenbaum, Michael
Boulman, Nina
Slobodin, Gleb
Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy
title Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy
title_full Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy
title_fullStr Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy
title_full_unstemmed Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy
title_short Q Fever Risk in Patients Treated with Chronic Antitumor Necrosis Factor-Alpha Therapy
title_sort q fever risk in patients treated with chronic antitumor necrosis factor-alpha therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021454/
https://www.ncbi.nlm.nih.gov/pubmed/27656302
http://dx.doi.org/10.1155/2016/4586150
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