Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine

Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here...

Descripción completa

Detalles Bibliográficos
Autores principales: Zollars, Eric, Courtney, Sean M., Wolf, Bethany J., Allaire, Norm, Ranger, Ann, Hardiman, Gary, Petri, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021495/
https://www.ncbi.nlm.nih.gov/pubmed/27656648
http://dx.doi.org/10.1155/2016/7862962
_version_ 1782453355517313024
author Zollars, Eric
Courtney, Sean M.
Wolf, Bethany J.
Allaire, Norm
Ranger, Ann
Hardiman, Gary
Petri, Michelle
author_facet Zollars, Eric
Courtney, Sean M.
Wolf, Bethany J.
Allaire, Norm
Ranger, Ann
Hardiman, Gary
Petri, Michelle
author_sort Zollars, Eric
collection PubMed
description Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus—specifically lupus nephritis.
format Online
Article
Text
id pubmed-5021495
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-50214952016-09-21 Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine Zollars, Eric Courtney, Sean M. Wolf, Bethany J. Allaire, Norm Ranger, Ann Hardiman, Gary Petri, Michelle Int J Genomics Research Article Monitoring disease activity in a complex, heterogeneous disease such as lupus is difficult. Both over- and undertreatment lead to damage. Current standard of care serologies are unreliable. Better measures of disease activity are necessary as we move into the era of precision medicine. We show here the use of a data-driven, modular approach to genomic biomarker development within lupus—specifically lupus nephritis. Hindawi Publishing Corporation 2016 2016-08-30 /pmc/articles/PMC5021495/ /pubmed/27656648 http://dx.doi.org/10.1155/2016/7862962 Text en Copyright © 2016 Eric Zollars et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zollars, Eric
Courtney, Sean M.
Wolf, Bethany J.
Allaire, Norm
Ranger, Ann
Hardiman, Gary
Petri, Michelle
Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine
title Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine
title_full Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine
title_fullStr Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine
title_full_unstemmed Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine
title_short Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine
title_sort clinical application of a modular genomics technique in systemic lupus erythematosus: progress towards precision medicine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021495/
https://www.ncbi.nlm.nih.gov/pubmed/27656648
http://dx.doi.org/10.1155/2016/7862962
work_keys_str_mv AT zollarseric clinicalapplicationofamodulargenomicstechniqueinsystemiclupuserythematosusprogresstowardsprecisionmedicine
AT courtneyseanm clinicalapplicationofamodulargenomicstechniqueinsystemiclupuserythematosusprogresstowardsprecisionmedicine
AT wolfbethanyj clinicalapplicationofamodulargenomicstechniqueinsystemiclupuserythematosusprogresstowardsprecisionmedicine
AT allairenorm clinicalapplicationofamodulargenomicstechniqueinsystemiclupuserythematosusprogresstowardsprecisionmedicine
AT rangerann clinicalapplicationofamodulargenomicstechniqueinsystemiclupuserythematosusprogresstowardsprecisionmedicine
AT hardimangary clinicalapplicationofamodulargenomicstechniqueinsystemiclupuserythematosusprogresstowardsprecisionmedicine
AT petrimichelle clinicalapplicationofamodulargenomicstechniqueinsystemiclupuserythematosusprogresstowardsprecisionmedicine

Ejemplares similares