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The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

OBJECTIVE: Leptin reverses hyperglycemia in rodent models of type 1 diabetes (T1D). Direct application of leptin to the brain can lower blood glucose in diabetic rodents, and can activate autonomic efferents and non-shivering thermogenesis in brown adipose tissue (BAT). We investigated whether lepti...

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Detalles Bibliográficos
Autores principales:	Denroche, Heather C., Kwon, Michelle M., Glavas, Maria M., Tudurí, Eva, Philippe, Marion, Quong, Whitney L., Kieffer, Timothy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021671/ https://www.ncbi.nlm.nih.gov/pubmed/27656409 http://dx.doi.org/10.1016/j.molmet.2016.06.009

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