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An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

OBJECTIVE: Transport of pyruvate into the mitochondrial matrix by the Mitochondrial Pyruvate Carrier (MPC) is an important and rate-limiting step in its metabolism. In pancreatic β-cells, mitochondrial pyruvate metabolism is thought to be important for glucose sensing and glucose-stimulated insulin...

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Detalles Bibliográficos
Autores principales:	McCommis, Kyle S., Hodges, Wesley T., Bricker, Daniel K., Wisidagama, Dona R., Compan, Vincent, Remedi, Maria S., Thummel, Carl S., Finck, Brian N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021712/ https://www.ncbi.nlm.nih.gov/pubmed/27656398 http://dx.doi.org/10.1016/j.molmet.2016.06.016

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