Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study

Combining Lipinski’s rule with the docking and steered molecular dynamics simulations and using the PubChem data base of about 1.4 million compounds, we have obtained DNA dyes Hoechst 34580 and Hoechst 33342 as top-leads for the Alzheimer’s disease. The binding properties of these ligands to amyloid...

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Detalles Bibliográficos
Autores principales: Thai, Nguyen Quoc, Tseng, Ning-Hsuan, Vu, Mui Thi, Nguyen, Tin Trung, Linh, Huynh Quang, Hu, Chin-Kun, Chen, Yun-Ru, Li, Mai Suan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021751/
https://www.ncbi.nlm.nih.gov/pubmed/27511370
http://dx.doi.org/10.1007/s10822-016-9932-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021751/
https://www.ncbi.nlm.nih.gov/pubmed/27511370
http://dx.doi.org/10.1007/s10822-016-9932-1

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