Does Weight Impact Anidulafungin Pharmacokinetics?

Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared wi...

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Autores principales: Lempers, Vincent J., van Rongen, Anne, van Dongen, Eric P., van Ramshorst, Bert, Burger, David M., Aarnoutse, Rob E., Knibbe, Catherijne A., Brüggemann, Roger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021753/
https://www.ncbi.nlm.nih.gov/pubmed/27142114
http://dx.doi.org/10.1007/s40262-016-0401-8
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author Lempers, Vincent J.
van Rongen, Anne
van Dongen, Eric P.
van Ramshorst, Bert
Burger, David M.
Aarnoutse, Rob E.
Knibbe, Catherijne A.
Brüggemann, Roger J.
author_facet Lempers, Vincent J.
van Rongen, Anne
van Dongen, Eric P.
van Ramshorst, Bert
Burger, David M.
Aarnoutse, Rob E.
Knibbe, Catherijne A.
Brüggemann, Roger J.
author_sort Lempers, Vincent J.
collection PubMed
description Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose increases may be required in this population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40262-016-0401-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-50217532016-09-27 Does Weight Impact Anidulafungin Pharmacokinetics? Lempers, Vincent J. van Rongen, Anne van Dongen, Eric P. van Ramshorst, Bert Burger, David M. Aarnoutse, Rob E. Knibbe, Catherijne A. Brüggemann, Roger J. Clin Pharmacokinet Short Communication Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose increases may be required in this population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40262-016-0401-8) contains supplementary material, which is available to authorized users. Springer International Publishing 2016-05-03 2016 /pmc/articles/PMC5021753/ /pubmed/27142114 http://dx.doi.org/10.1007/s40262-016-0401-8 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Communication
Lempers, Vincent J.
van Rongen, Anne
van Dongen, Eric P.
van Ramshorst, Bert
Burger, David M.
Aarnoutse, Rob E.
Knibbe, Catherijne A.
Brüggemann, Roger J.
Does Weight Impact Anidulafungin Pharmacokinetics?
title Does Weight Impact Anidulafungin Pharmacokinetics?
title_full Does Weight Impact Anidulafungin Pharmacokinetics?
title_fullStr Does Weight Impact Anidulafungin Pharmacokinetics?
title_full_unstemmed Does Weight Impact Anidulafungin Pharmacokinetics?
title_short Does Weight Impact Anidulafungin Pharmacokinetics?
title_sort does weight impact anidulafungin pharmacokinetics?
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021753/
https://www.ncbi.nlm.nih.gov/pubmed/27142114
http://dx.doi.org/10.1007/s40262-016-0401-8
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