Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection

We present a 71-year old woman treated with 14 days of 5 mg intraventricular caspofungin for Scedosporium apiospermum complex meningoencephalitis diagnosed after spinal fusion and instrumentation. Cerebrospinal fluid studies improved during therapy and intraventricular administration was well tolera...

Descripción completa

Detalles Bibliográficos
Autores principales: Williams, John R., Tenforde, Mark W., Chan, Jeannie D., Ko, Andrew, Graham, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021765/
https://www.ncbi.nlm.nih.gov/pubmed/27656356
http://dx.doi.org/10.1016/j.mmcr.2016.07.003
_version_ 1782453387690770432
author Williams, John R.
Tenforde, Mark W.
Chan, Jeannie D.
Ko, Andrew
Graham, Susan M.
author_facet Williams, John R.
Tenforde, Mark W.
Chan, Jeannie D.
Ko, Andrew
Graham, Susan M.
author_sort Williams, John R.
collection PubMed
description We present a 71-year old woman treated with 14 days of 5 mg intraventricular caspofungin for Scedosporium apiospermum complex meningoencephalitis diagnosed after spinal fusion and instrumentation. Cerebrospinal fluid studies improved during therapy and intraventricular administration was well tolerated. Within weeks of discontinuation, the patient experienced clinical deterioration with disease progression. There are sparse data on the efficacy and safety of administering intraventricular caspofungin. While apparently safe, intraventricular caspofungin was insufficient for disease control in this case.
format Online
Article
Text
id pubmed-5021765
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-50217652016-09-21 Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection Williams, John R. Tenforde, Mark W. Chan, Jeannie D. Ko, Andrew Graham, Susan M. Med Mycol Case Rep Case Report We present a 71-year old woman treated with 14 days of 5 mg intraventricular caspofungin for Scedosporium apiospermum complex meningoencephalitis diagnosed after spinal fusion and instrumentation. Cerebrospinal fluid studies improved during therapy and intraventricular administration was well tolerated. Within weeks of discontinuation, the patient experienced clinical deterioration with disease progression. There are sparse data on the efficacy and safety of administering intraventricular caspofungin. While apparently safe, intraventricular caspofungin was insufficient for disease control in this case. Elsevier 2016-07-09 /pmc/articles/PMC5021765/ /pubmed/27656356 http://dx.doi.org/10.1016/j.mmcr.2016.07.003 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Williams, John R.
Tenforde, Mark W.
Chan, Jeannie D.
Ko, Andrew
Graham, Susan M.
Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection
title Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection
title_full Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection
title_fullStr Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection
title_full_unstemmed Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection
title_short Safety and clinical response of intraventricular caspofungin for Scedosporium apiospermum complex central nervous system infection
title_sort safety and clinical response of intraventricular caspofungin for scedosporium apiospermum complex central nervous system infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021765/
https://www.ncbi.nlm.nih.gov/pubmed/27656356
http://dx.doi.org/10.1016/j.mmcr.2016.07.003
work_keys_str_mv AT williamsjohnr safetyandclinicalresponseofintraventricularcaspofunginforscedosporiumapiospermumcomplexcentralnervoussysteminfection
AT tenfordemarkw safetyandclinicalresponseofintraventricularcaspofunginforscedosporiumapiospermumcomplexcentralnervoussysteminfection
AT chanjeannied safetyandclinicalresponseofintraventricularcaspofunginforscedosporiumapiospermumcomplexcentralnervoussysteminfection
AT koandrew safetyandclinicalresponseofintraventricularcaspofunginforscedosporiumapiospermumcomplexcentralnervoussysteminfection
AT grahamsusanm safetyandclinicalresponseofintraventricularcaspofunginforscedosporiumapiospermumcomplexcentralnervoussysteminfection

Ejemplares similares