Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line

The relationship between P-gp and CD147 in the regulation of MDR in leukemic cells has not been reported. This study aimed to investigate the correlation between CD147 and P-gp in the regulation of drug resistance in the K562/ADR leukemic cell line. The results showed that drug-resistant K562/ADR ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Somno, Aoranit, Anuchapreeda, Songyot, Chruewkamlow, Nuttapol, Pata, Supansa, Kasinrerk, Watchara, Chiampanichayakul, Sawitree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021772/
https://www.ncbi.nlm.nih.gov/pubmed/27656412
http://dx.doi.org/10.1016/j.lrr.2016.08.001
_version_ 1782453389094813696
author Somno, Aoranit
Anuchapreeda, Songyot
Chruewkamlow, Nuttapol
Pata, Supansa
Kasinrerk, Watchara
Chiampanichayakul, Sawitree
author_facet Somno, Aoranit
Anuchapreeda, Songyot
Chruewkamlow, Nuttapol
Pata, Supansa
Kasinrerk, Watchara
Chiampanichayakul, Sawitree
author_sort Somno, Aoranit
collection PubMed
description The relationship between P-gp and CD147 in the regulation of MDR in leukemic cells has not been reported. This study aimed to investigate the correlation between CD147 and P-gp in the regulation of drug resistance in the K562/ADR leukemic cell line. The results showed that drug-resistant K562/ADR cells expressed significantly higher P-gp and CD147 levels than drug-free K562/ADR cells. To determine the regulatory effect of CD147 on P-gp expression, anti-CD147 antibody MEM-M6/6 significantly decreased P-gp and CD147 mRNA and protein levels. This is the first report to show that CD147 mediates MDR in leukemia through the regulation of P-gp expression.
format Online
Article
Text
id pubmed-5021772
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-50217722016-09-21 Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line Somno, Aoranit Anuchapreeda, Songyot Chruewkamlow, Nuttapol Pata, Supansa Kasinrerk, Watchara Chiampanichayakul, Sawitree Leuk Res Rep Article The relationship between P-gp and CD147 in the regulation of MDR in leukemic cells has not been reported. This study aimed to investigate the correlation between CD147 and P-gp in the regulation of drug resistance in the K562/ADR leukemic cell line. The results showed that drug-resistant K562/ADR cells expressed significantly higher P-gp and CD147 levels than drug-free K562/ADR cells. To determine the regulatory effect of CD147 on P-gp expression, anti-CD147 antibody MEM-M6/6 significantly decreased P-gp and CD147 mRNA and protein levels. This is the first report to show that CD147 mediates MDR in leukemia through the regulation of P-gp expression. Elsevier 2016-08-26 /pmc/articles/PMC5021772/ /pubmed/27656412 http://dx.doi.org/10.1016/j.lrr.2016.08.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Somno, Aoranit
Anuchapreeda, Songyot
Chruewkamlow, Nuttapol
Pata, Supansa
Kasinrerk, Watchara
Chiampanichayakul, Sawitree
Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line
title Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line
title_full Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line
title_fullStr Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line
title_full_unstemmed Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line
title_short Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line
title_sort involvement of cd147 on multidrug resistance through the regulation of p-glycoprotein expression in k562/adr leukemic cell line
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021772/
https://www.ncbi.nlm.nih.gov/pubmed/27656412
http://dx.doi.org/10.1016/j.lrr.2016.08.001
work_keys_str_mv AT somnoaoranit involvementofcd147onmultidrugresistancethroughtheregulationofpglycoproteinexpressionink562adrleukemiccellline
AT anuchapreedasongyot involvementofcd147onmultidrugresistancethroughtheregulationofpglycoproteinexpressionink562adrleukemiccellline
AT chruewkamlownuttapol involvementofcd147onmultidrugresistancethroughtheregulationofpglycoproteinexpressionink562adrleukemiccellline
AT patasupansa involvementofcd147onmultidrugresistancethroughtheregulationofpglycoproteinexpressionink562adrleukemiccellline
AT kasinrerkwatchara involvementofcd147onmultidrugresistancethroughtheregulationofpglycoproteinexpressionink562adrleukemiccellline
AT chiampanichayakulsawitree involvementofcd147onmultidrugresistancethroughtheregulationofpglycoproteinexpressionink562adrleukemiccellline

Ejemplares similares