Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail

Apical membrane antigen 1 (AMA1) is a receptor protein on the surface of Toxoplasma gondii that plays a critical role in host cell invasion. The ligand to which T. gondii AMA1 (TgAMA1) binds, TgRON2, is secreted into the host cell membrane by the parasite during the early stages of invasion. The TgA...

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Detalles Bibliográficos
Autores principales: Krishnamurthy, Shruthi, Deng, Bin, del Rio, Roxana, Buchholz, Kerry R., Treeck, Moritz, Urban, Siniša, Boothroyd, John, Lam, Ying-Wai, Ward, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021801/
https://www.ncbi.nlm.nih.gov/pubmed/27624124
http://dx.doi.org/10.1128/mBio.00754-16

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