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An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity

Research on marine natural products as potential anticancer agents is still limited. In the present study, an aqueous extract of a Canadian marine microalgal preparation was assessed for anticancer activities using various assays and cell lines of human cancers, including lung, prostate, stomach, br...

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Autores principales: Somasekharan, Syam Prakash, El-Naggar, Amal, Sorensen, Poul H., Wang, Yuzhuo, Cheng, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021869/
https://www.ncbi.nlm.nih.gov/pubmed/27656243
http://dx.doi.org/10.1155/2016/9730654
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author Somasekharan, Syam Prakash
El-Naggar, Amal
Sorensen, Poul H.
Wang, Yuzhuo
Cheng, Hongwei
author_facet Somasekharan, Syam Prakash
El-Naggar, Amal
Sorensen, Poul H.
Wang, Yuzhuo
Cheng, Hongwei
author_sort Somasekharan, Syam Prakash
collection PubMed
description Research on marine natural products as potential anticancer agents is still limited. In the present study, an aqueous extract of a Canadian marine microalgal preparation was assessed for anticancer activities using various assays and cell lines of human cancers, including lung, prostate, stomach, breast, and pancreatic cancers, as well as an osteosarcoma. In vitro, the microalgal extract exhibited marked anticolony forming activity. In addition, it was more toxic, as indicated by increased apoptosis, to nonadherent cells (grown in suspension) than to adherent cells. In vivo, an antimetastatic effect of the extract was observed in NOD-SCID mice carrying subrenal capsule xenografts of PC3 prostate cancer cells. The results of the present study suggest that the antimetastatic effect of the aqueous microalgal extract is based on inhibition of colony forming ability of cancer cells and the preferential killing of suspended cancer cells. Further research aimed at identification of the molecular basis of the anticancer activities of the microalgal extract appears to be warranted.
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spelling pubmed-50218692016-09-21 An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity Somasekharan, Syam Prakash El-Naggar, Amal Sorensen, Poul H. Wang, Yuzhuo Cheng, Hongwei Evid Based Complement Alternat Med Research Article Research on marine natural products as potential anticancer agents is still limited. In the present study, an aqueous extract of a Canadian marine microalgal preparation was assessed for anticancer activities using various assays and cell lines of human cancers, including lung, prostate, stomach, breast, and pancreatic cancers, as well as an osteosarcoma. In vitro, the microalgal extract exhibited marked anticolony forming activity. In addition, it was more toxic, as indicated by increased apoptosis, to nonadherent cells (grown in suspension) than to adherent cells. In vivo, an antimetastatic effect of the extract was observed in NOD-SCID mice carrying subrenal capsule xenografts of PC3 prostate cancer cells. The results of the present study suggest that the antimetastatic effect of the aqueous microalgal extract is based on inhibition of colony forming ability of cancer cells and the preferential killing of suspended cancer cells. Further research aimed at identification of the molecular basis of the anticancer activities of the microalgal extract appears to be warranted. Hindawi Publishing Corporation 2016 2016-08-31 /pmc/articles/PMC5021869/ /pubmed/27656243 http://dx.doi.org/10.1155/2016/9730654 Text en Copyright © 2016 Syam Prakash Somasekharan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Somasekharan, Syam Prakash
El-Naggar, Amal
Sorensen, Poul H.
Wang, Yuzhuo
Cheng, Hongwei
An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity
title An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity
title_full An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity
title_fullStr An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity
title_full_unstemmed An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity
title_short An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity
title_sort aqueous extract of marine microalgae exhibits antimetastatic activity through preferential killing of suspended cancer cells and anticolony forming activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021869/
https://www.ncbi.nlm.nih.gov/pubmed/27656243
http://dx.doi.org/10.1155/2016/9730654
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