TRPM4-mediated control of FcεRI-evoked Ca(2+) elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells

TRPM4 proteins form Ca(2+)-activated non selective cation (CAN) channels that affect transmembrane Ca(2+)-influx by determining the membrane potential. Tight control of the intracellular Ca(2+) concentration is essential for mast cell responses. In this study, we analyzed the expression of TRPM4 in...

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Detalles Bibliográficos
Autores principales: Rixecker, Torben, Mathar, Ilka, Medert, Rebekka, Mannebach, Stefanie, Pfeifer, Alexander, Lipp, Peter, Tsvilovskyy, Volodymyr, Freichel, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021962/
https://www.ncbi.nlm.nih.gov/pubmed/27624684
http://dx.doi.org/10.1038/srep32981

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