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Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer

The application of optical absorption spectra in prognostic prediction has hardly been investigated. We developed and evaluated a novel two dimensional absorption spectrum measurement system (TDAS) for use in early diagnosis, evaluating response to chemoradiation, and making prognostic prediction. T...

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Autores principales: Yang, Pei-Wen, Hsu, I-Jen, Chang, Chun-Wei, Wang, Yu-Chia, Hsieh, Ching-Yueh, Shih, Kuan-Hui, Wong, Li-Fan, Shih, Nai-Yu, Hsieh, Min-Shu, Hou, Max Ti-Kuang, Lee, Jang-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022060/
https://www.ncbi.nlm.nih.gov/pubmed/27624872
http://dx.doi.org/10.1038/srep33414
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author Yang, Pei-Wen
Hsu, I-Jen
Chang, Chun-Wei
Wang, Yu-Chia
Hsieh, Ching-Yueh
Shih, Kuan-Hui
Wong, Li-Fan
Shih, Nai-Yu
Hsieh, Min-Shu
Hou, Max Ti-Kuang
Lee, Jang-Ming
author_facet Yang, Pei-Wen
Hsu, I-Jen
Chang, Chun-Wei
Wang, Yu-Chia
Hsieh, Ching-Yueh
Shih, Kuan-Hui
Wong, Li-Fan
Shih, Nai-Yu
Hsieh, Min-Shu
Hou, Max Ti-Kuang
Lee, Jang-Ming
author_sort Yang, Pei-Wen
collection PubMed
description The application of optical absorption spectra in prognostic prediction has hardly been investigated. We developed and evaluated a novel two dimensional absorption spectrum measurement system (TDAS) for use in early diagnosis, evaluating response to chemoradiation, and making prognostic prediction. The absorption spectra of 120 sets of normal and tumor tissues from esophageal cancer patients were analyzed with TDAS ex-vivo. We demonstrated the cancerous tissue, the tissue from patients with a poor concurrent chemoradiotherapy (CCRT) response, and the tissue from patients with an early disease progression each had a readily identifiable common spectral signature. Principal component analysis (PCA) classified tissue spectra into distinct groups, demonstrating the feasibility of using absorption spectra in differentiating normal and tumor tissues, and in predicting CCRT response, poor survival and tumor recurrence (efficiencies of 75%, 100% and 85.7% respectively). Multivariate analysis revealed that patients identified as having poor-response, poor-survival and recurrence spectral signatures were correlated with increased risk of poor response to CCRT (P = 0.012), increased risk of death (P = 0.111) and increased risk of recurrence (P = 0.030) respectively. Our findings suggest that optical absorption microscopy has great potential to be a useful tool for pre-operative diagnosis and prognostic prediction of esophageal cancer.
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spelling pubmed-50220602016-09-20 Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer Yang, Pei-Wen Hsu, I-Jen Chang, Chun-Wei Wang, Yu-Chia Hsieh, Ching-Yueh Shih, Kuan-Hui Wong, Li-Fan Shih, Nai-Yu Hsieh, Min-Shu Hou, Max Ti-Kuang Lee, Jang-Ming Sci Rep Article The application of optical absorption spectra in prognostic prediction has hardly been investigated. We developed and evaluated a novel two dimensional absorption spectrum measurement system (TDAS) for use in early diagnosis, evaluating response to chemoradiation, and making prognostic prediction. The absorption spectra of 120 sets of normal and tumor tissues from esophageal cancer patients were analyzed with TDAS ex-vivo. We demonstrated the cancerous tissue, the tissue from patients with a poor concurrent chemoradiotherapy (CCRT) response, and the tissue from patients with an early disease progression each had a readily identifiable common spectral signature. Principal component analysis (PCA) classified tissue spectra into distinct groups, demonstrating the feasibility of using absorption spectra in differentiating normal and tumor tissues, and in predicting CCRT response, poor survival and tumor recurrence (efficiencies of 75%, 100% and 85.7% respectively). Multivariate analysis revealed that patients identified as having poor-response, poor-survival and recurrence spectral signatures were correlated with increased risk of poor response to CCRT (P = 0.012), increased risk of death (P = 0.111) and increased risk of recurrence (P = 0.030) respectively. Our findings suggest that optical absorption microscopy has great potential to be a useful tool for pre-operative diagnosis and prognostic prediction of esophageal cancer. Nature Publishing Group 2016-09-14 /pmc/articles/PMC5022060/ /pubmed/27624872 http://dx.doi.org/10.1038/srep33414 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Yang, Pei-Wen
Hsu, I-Jen
Chang, Chun-Wei
Wang, Yu-Chia
Hsieh, Ching-Yueh
Shih, Kuan-Hui
Wong, Li-Fan
Shih, Nai-Yu
Hsieh, Min-Shu
Hou, Max Ti-Kuang
Lee, Jang-Ming
Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer
title Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer
title_full Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer
title_fullStr Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer
title_full_unstemmed Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer
title_short Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer
title_sort visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022060/
https://www.ncbi.nlm.nih.gov/pubmed/27624872
http://dx.doi.org/10.1038/srep33414
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