Region-specific alterations of A-to-I RNA editing of serotonin 2c receptor in the cortex of suicides with major depression

Brain region-specific abnormalities in serotonergic transmission appear to underlie suicidal behavior. Alterations of RNA editing on the serotonin receptor 2C (HTR2C) pre-mRNA in the brain of suicides produce transcripts that attenuate 5-HT(2C)R signaling by impairing intracellular G-protein couplin...

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Detalles Bibliográficos
Autores principales: Weissmann, D, van der Laan, S, Underwood, M D, Salvetat, N, Cavarec, L, Vincent, L, Molina, F, Mann, J J, Arango, V, Pujol, J F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022077/
https://www.ncbi.nlm.nih.gov/pubmed/27576167
http://dx.doi.org/10.1038/tp.2016.121

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