Cargando…

Leveraging electronic health records to study pleiotropic effects on bipolar disorder and medical comorbidities

Patients with bipolar disorder (BD) have a high prevalence of comorbid medical illness. However, the mechanisms underlying these comorbidities with BD are not well known. Certain genetic variants may have pleiotropic effects, increasing the risk of BD and other medical illnesses simultaneously. In t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prieto, M L, Ryu, E, Jenkins, G D, Batzler, A, Nassan, M M, Cuellar-Barboza, A B, Pathak, J, McElroy, S L, Frye, M A, Biernacka, J M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022084/ https://www.ncbi.nlm.nih.gov/pubmed/27529678 http://dx.doi.org/10.1038/tp.2016.138

Ejemplares similares

Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8
por: McElroy, Susan L., et al.
Publicado: (2018)

Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses
por: Frye, Mark A, et al.
Publicado: (2015)

Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder
por: Markota, Matej, et al.
Publicado: (2018)

Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder
por: Jons, William A., et al.
Publicado: (2019)

Potential pharmacogenomic targets in bipolar disorder: considerations for current testing and the development of decision support tools to individualize treatment selection
por: Cuéllar-Barboza, Alfredo B., et al.
Publicado: (2020)

Mood‐Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome‐Wide Association Study
por: Ho, Ada Man‐Choi, et al.
Publicado: (2020)

Dissecting clinical heterogeneity of bipolar disorder using multiple polygenic risk scores
por: Coombes, Brandon J., et al.
Publicado: (2020)

Long-Term Lithium Therapy and Thyroid Disorders in Bipolar Disorder: A Historical Cohort Study
por: Joseph, Boney, et al.
Publicado: (2023)

Clinical and Genetic Correlates of Bipolar Disorder With Childhood-Onset Attention Deficit Disorder
por: Nunez, Nicolas A., et al.
Publicado: (2022)

Clinical Correlates of Cardiac Conduction in Bipolar Disorder
por: Prieto, M., et al.
Publicado: (2022)

Differential SLC1A2 Promoter Methylation in Bipolar Disorder With or Without Addiction
por: Jia, Yun-Fang, et al.
Publicado: (2017)

25 Years of the International Bipolar Collaborative Network (BCN)
por: Post, Robert M., et al.
Publicado: (2021)

Racial disparities in bipolar disorder treatment and research: a call to action
por: Akinhanmi, Margaret O, et al.
Publicado: (2018)

Antidepressant-Associated Treatment Emergent Mania: A Meta-Analysis to Guide Risk Modeling Pharmacogenomic Targets of Potential Clinical Value
por: Nuñez, Nicolas A., et al.
Publicado: (2023)

Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania
por: Gardea-Resendez, Manuel, et al.
Publicado: (2022)

Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders
por: Frye, M A, et al.
Publicado: (2015)

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS
por: Wang, Yunpeng, et al.
Publicado: (2016)

Leveraging an Electronic Health Record-Linked Biorepository to Generate a Metformin Pharmacogenomics Hypothesis
por: Breitenstein, Matthew K., et al.
Publicado: (2015)

Mania and bipolar depression: complementing not opposing poles—a post-hoc analysis of mixed features in manic and hypomanic episodes
por: Born, Christoph, et al.
Publicado: (2021)

Predictors of psychosocial outcome of bipolar disorder: data from the Stanley Foundation Bipolar Network
por: Bennett, Francis, et al.
Publicado: (2019)

Self‐report screening instruments differentiate bipolar disorder and borderline personality disorder
por: Palmer, Brian A., et al.
Publicado: (2021)

Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder
por: Lundberg, Martin, et al.
Publicado: (2020)

The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder
por: Riemann, Georg, et al.
Publicado: (2017)

Leveraging pleiotropic association using sparse group variable selection in genomics data
por: Sutton, Matthew, et al.
Publicado: (2022)

Editorial: Neurobiological Underpinnings of Bipolar Disorder and Its Treatment
por: Singh, Balwinder, et al.
Publicado: (2021)

Testing a clinical staging model for bipolar disorder using longitudinal life chart data
por: van der Markt, Afra, et al.
Publicado: (2018)

Comorbid medical illness in bipolar disorder
por: Forty, Liz, et al.
Publicado: (2014)

2040 Symptom endorsement in bipolar patients of African Versus European ancestry
por: Akinhanmi, Margaret, et al.
Publicado: (2018)

Detecting Associations between Major Depressive Disorder Treatment and Essential Hypertension using Electronic Health Records
por: Pathak, Jyotishman, et al.
Publicado: (2014)

Complex trait architecture: the pleiotropic model revisited
por: North, T.-L., et al.
Publicado: (2015)

Leveraging Electronic Health Records to Address Breast Cancer Disparities
por: Bayard, Solange, et al.
Publicado: (2022)

Leveraging an electronic health record note template to standardize screening and testing for COVID-19
por: Deeds, Stefanie A., et al.
Publicado: (2020)

Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk
por: McGrath, Isabelle M., et al.
Publicado: (2023)

TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics
por: Gupta, M, et al.
Publicado: (2016)

Rapid cycling as a feature of bipolar disorder and comorbid migraine
por: Gordon-Smith, K., et al.
Publicado: (2015)

PS45. SLC1A2 Promoter is Hypomethylated in Bipolar Disorder with Comorbid Addiction
por: Veldic, Marin, et al.
Publicado: (2016)

Sleep disturbances in bipolar disorder with comorbid post-traumatic stress disorder
por: Cruz Sanabria, F., et al.
Publicado: (2023)

Call to action regarding the vascular‐bipolar link: A report from the Vascular Task Force of the International Society for Bipolar Disorders
por: Goldstein, Benjamin I., et al.
Publicado: (2020)

Leveraging the Electronic Health Record to Address the COVID-19 Pandemic
por: Satterfield, Benjamin A., et al.
Publicado: (2021)

180. Leveraging the Electronic Medical Record as a Method of Antibiotic Stewardship
por: Kaul, Christina M, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jpsqgipnn0mhjr6vq40ar29njo