Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated research into carriers that can protect it from ribonucleases and as such enable its systemic use. However, carrier-mediated delivery of mRNA has been linked to production of type I interferon (IFN) that...

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Detalles Bibliográficos
Autores principales: Broos, Katrijn, Van der Jeught, Kevin, Puttemans, Janik, Goyvaerts, Cleo, Heirman, Carlo, Dewitte, Heleen, Verbeke, Rein, Lentacker, Ine, Thielemans, Kris, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022130/
https://www.ncbi.nlm.nih.gov/pubmed/27327138
http://dx.doi.org/10.1038/mtna.2016.38

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