Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice

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Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture aug...

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Detalles Bibliográficos
Autores principales: Cao, Limin, Han, Gang, Lin, Caorui, Gu, Ben, Gao, Xianjun, Moulton, Hong M, Seow, Yiqi, Yin, HaiFang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022132/
https://www.ncbi.nlm.nih.gov/pubmed/27351681
http://dx.doi.org/10.1038/mtna.2016.46
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