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Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children
OBJECTIVE: Postural tachycardia syndrome (POTS) is one of the major causes of orthostatic intolerance in children. We systematically reviewed the pathogenesis and the progress of individualized treatment for POTS in children. DATA SOURCES: The data analyzed in this review are mainly from articles in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022347/ https://www.ncbi.nlm.nih.gov/pubmed/27625098 http://dx.doi.org/10.4103/0366-6999.189915 |
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author | Xu, Wen-Rui Jin, Hong-Fang Du, Jun-Bao |
author_facet | Xu, Wen-Rui Jin, Hong-Fang Du, Jun-Bao |
author_sort | Xu, Wen-Rui |
collection | PubMed |
description | OBJECTIVE: Postural tachycardia syndrome (POTS) is one of the major causes of orthostatic intolerance in children. We systematically reviewed the pathogenesis and the progress of individualized treatment for POTS in children. DATA SOURCES: The data analyzed in this review are mainly from articles included in PubMed and EMBASE. STUDY SELECTION: The original articles and critical reviews about POTS were selected for this review. RESULTS: Studies have shown that POTS might be related to several factors including hypovolemia, high catecholamine status, abnormal local vascular tension, and decreased skeletal muscle pump activity. In addition to exercise training, the first-line treatments mainly include oral rehydration salts, beta-adrenoreceptor blockers, and alpha-adrenoreceptor agonists. However, reports about the effectiveness of various treatments are diverse. By analyzing the patient's physiological indexes and biomarkers before the treatment, the efficacy of medication could be well predicted. CONCLUSIONS: The pathogenesis of POTS is multifactorial, including hypovolemia, abnormal catecholamine state, and vascular dysfunction. Biomarker-directed individualized treatment is an important strategy for the management of POTS children. |
format | Online Article Text |
id | pubmed-5022347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-50223472016-09-21 Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children Xu, Wen-Rui Jin, Hong-Fang Du, Jun-Bao Chin Med J (Engl) Review Article OBJECTIVE: Postural tachycardia syndrome (POTS) is one of the major causes of orthostatic intolerance in children. We systematically reviewed the pathogenesis and the progress of individualized treatment for POTS in children. DATA SOURCES: The data analyzed in this review are mainly from articles included in PubMed and EMBASE. STUDY SELECTION: The original articles and critical reviews about POTS were selected for this review. RESULTS: Studies have shown that POTS might be related to several factors including hypovolemia, high catecholamine status, abnormal local vascular tension, and decreased skeletal muscle pump activity. In addition to exercise training, the first-line treatments mainly include oral rehydration salts, beta-adrenoreceptor blockers, and alpha-adrenoreceptor agonists. However, reports about the effectiveness of various treatments are diverse. By analyzing the patient's physiological indexes and biomarkers before the treatment, the efficacy of medication could be well predicted. CONCLUSIONS: The pathogenesis of POTS is multifactorial, including hypovolemia, abnormal catecholamine state, and vascular dysfunction. Biomarker-directed individualized treatment is an important strategy for the management of POTS children. Medknow Publications & Media Pvt Ltd 2016-09-20 /pmc/articles/PMC5022347/ /pubmed/27625098 http://dx.doi.org/10.4103/0366-6999.189915 Text en Copyright: © 2016 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Xu, Wen-Rui Jin, Hong-Fang Du, Jun-Bao Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children |
title | Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children |
title_full | Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children |
title_fullStr | Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children |
title_full_unstemmed | Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children |
title_short | Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children |
title_sort | pathogenesis and individualized treatment for postural tachycardia syndrome in children |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022347/ https://www.ncbi.nlm.nih.gov/pubmed/27625098 http://dx.doi.org/10.4103/0366-6999.189915 |
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