Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators

Vaccinia virus (VACV)-derived vectors are popular candidates for vaccination against diseases such as HIV-1, malaria and tuberculosis. However, their genomes encode a multitude of proteins with immunomodulatory functions, several of which reduce the immunogenicity of these vectors. Hitherto only lim...

Descripción completa

Detalles Bibliográficos
Autores principales: Sumner, Rebecca P., Ren, Hongwei, Ferguson, Brian J., Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022402/
https://www.ncbi.nlm.nih.gov/pubmed/27544585
http://dx.doi.org/10.1016/j.vaccine.2016.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022402/
https://www.ncbi.nlm.nih.gov/pubmed/27544585
http://dx.doi.org/10.1016/j.vaccine.2016.08.002

Ejemplares similares