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Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators

Vaccinia virus (VACV)-derived vectors are popular candidates for vaccination against diseases such as HIV-1, malaria and tuberculosis. However, their genomes encode a multitude of proteins with immunomodulatory functions, several of which reduce the immunogenicity of these vectors. Hitherto only lim...

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Detalles Bibliográficos
Autores principales:	Sumner, Rebecca P., Ren, Hongwei, Ferguson, Brian J., Smith, Geoffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022402/ https://www.ncbi.nlm.nih.gov/pubmed/27544585 http://dx.doi.org/10.1016/j.vaccine.2016.08.002

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