Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

[Image: see text] Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecu...

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Autores principales: Haftchenary, Sina, Nelson, Shawn D., Furst, Laura, Dandapani, Sivaraman, Ferrara, Steven J., Bošković, Žarko V., Figueroa Lazú, Samuel, Guerrero, Adrian M., Serrano, Juan C., Crews, DeMarcus K., Brackeen, Cristina, Mowat, Jeffrey, Brumby, Thomas, Bauser, Marcus, Schreiber, Stuart L., Phillips, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022782/
https://www.ncbi.nlm.nih.gov/pubmed/27518324
http://dx.doi.org/10.1021/acscombsci.6b00050
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author Haftchenary, Sina
Nelson, Shawn D.
Furst, Laura
Dandapani, Sivaraman
Ferrara, Steven J.
Bošković, Žarko V.
Figueroa Lazú, Samuel
Guerrero, Adrian M.
Serrano, Juan C.
Crews, DeMarcus K.
Brackeen, Cristina
Mowat, Jeffrey
Brumby, Thomas
Bauser, Marcus
Schreiber, Stuart L.
Phillips, Andrew J.
author_facet Haftchenary, Sina
Nelson, Shawn D.
Furst, Laura
Dandapani, Sivaraman
Ferrara, Steven J.
Bošković, Žarko V.
Figueroa Lazú, Samuel
Guerrero, Adrian M.
Serrano, Juan C.
Crews, DeMarcus K.
Brackeen, Cristina
Mowat, Jeffrey
Brumby, Thomas
Bauser, Marcus
Schreiber, Stuart L.
Phillips, Andrew J.
author_sort Haftchenary, Sina
collection PubMed
description [Image: see text] Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).
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spelling pubmed-50227822017-08-12 Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments Haftchenary, Sina Nelson, Shawn D. Furst, Laura Dandapani, Sivaraman Ferrara, Steven J. Bošković, Žarko V. Figueroa Lazú, Samuel Guerrero, Adrian M. Serrano, Juan C. Crews, DeMarcus K. Brackeen, Cristina Mowat, Jeffrey Brumby, Thomas Bauser, Marcus Schreiber, Stuart L. Phillips, Andrew J. ACS Comb Sci [Image: see text] Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM). American Chemical Society 2016-08-12 2016-09-12 /pmc/articles/PMC5022782/ /pubmed/27518324 http://dx.doi.org/10.1021/acscombsci.6b00050 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Haftchenary, Sina
Nelson, Shawn D.
Furst, Laura
Dandapani, Sivaraman
Ferrara, Steven J.
Bošković, Žarko V.
Figueroa Lazú, Samuel
Guerrero, Adrian M.
Serrano, Juan C.
Crews, DeMarcus K.
Brackeen, Cristina
Mowat, Jeffrey
Brumby, Thomas
Bauser, Marcus
Schreiber, Stuart L.
Phillips, Andrew J.
Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
title Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
title_full Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
title_fullStr Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
title_full_unstemmed Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
title_short Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
title_sort efficient routes to a diverse array of amino alcohol-derived chiral fragments
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022782/
https://www.ncbi.nlm.nih.gov/pubmed/27518324
http://dx.doi.org/10.1021/acscombsci.6b00050
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