Synthesis of α-l-Threofuranosyl Nucleoside Triphosphates (tNTPs)

[Image: see text] The α-l-threofuranosyl nucleoside triphosphates of T, G, and D (tTTP, tGTP, and tDTP) were synthesized from the described 2‘-O-DMT-protected derivatives using the Eckstein method, while the corresponding C derivative (tCTP) was prepared from the 2‘-O-acetyl derivative. The prepared...

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Detalles Bibliográficos
Autores principales: Zou, Keyong, Horhota, Allen, Yu, Biao, Szostak, Jack W., McLaughlin, Larry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2005
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022784/
https://www.ncbi.nlm.nih.gov/pubmed/15816733
http://dx.doi.org/10.1021/ol050081+
Descripción
Sumario:[Image: see text] The α-l-threofuranosyl nucleoside triphosphates of T, G, and D (tTTP, tGTP, and tDTP) were synthesized from the described 2‘-O-DMT-protected derivatives using the Eckstein method, while the corresponding C derivative (tCTP) was prepared from the 2‘-O-acetyl derivative. The prepared α-l-threofuranosyl nucleoside triphosphates, despite being one carbon shorter than the native 2‘-deoxyfuranosyl nucleoside triphosphates, are effective substrates for selected DNA polymerases.

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