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Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence

Patient: Female, 11 Final Diagnosis: Hereditary gingival fibromatosis Symptoms: Gingival overgrowth Medication: — Clinical Procedure: Surgery Specialty: Dentistry OBJECTIVE: Rare disease BACKGROUND: Hereditary gingival fibromatosis is characterized by slowly progressive enlargement of the gingiva th...

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Autores principales: Gawron, Katarzyna, Łazarz-Bartyzel, Katarzyna, Fertala, Andrzej, Plakwicz, Paweł, Potempa, Jan, Chomyszyn-Gajewska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022846/
https://www.ncbi.nlm.nih.gov/pubmed/27609299
http://dx.doi.org/10.12659/AJCR.899997
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author Gawron, Katarzyna
Łazarz-Bartyzel, Katarzyna
Fertala, Andrzej
Plakwicz, Paweł
Potempa, Jan
Chomyszyn-Gajewska, Maria
author_facet Gawron, Katarzyna
Łazarz-Bartyzel, Katarzyna
Fertala, Andrzej
Plakwicz, Paweł
Potempa, Jan
Chomyszyn-Gajewska, Maria
author_sort Gawron, Katarzyna
collection PubMed
description Patient: Female, 11 Final Diagnosis: Hereditary gingival fibromatosis Symptoms: Gingival overgrowth Medication: — Clinical Procedure: Surgery Specialty: Dentistry OBJECTIVE: Rare disease BACKGROUND: Hereditary gingival fibromatosis is characterized by slowly progressive enlargement of the gingiva that can present as an isolated condition or a part of various syndromes. CASE REPORT: An 11-year-old female reported with a gingival lesion that caused masticatory problems and poor oral hygiene. Periodontal examination revealed a dense tissue covering 30% of her teeth crowns within both jaws. Panoramic x-ray showed a normal bone height and teeth positioning. The patient did not use any medications, but a similar condition was also present in other family members. The patient was diagnosed with hereditary gingival fibromatosis. Surgery was carried out to remove excess of gingival tissue. Post-surgical healing was uneventful, but four weeks after the first surgery, the condition recurred amounting to 45% of the initial tissue volume presenting in the mandible, and 25% in the maxilla. Two months later, no significant growth was noted in the mandible, while in the maxilla, growth increased to 40% of the pre-operative state. Analysis by polarized microscope showed a significant increase of thin fibrotic fibrils that contributed 80% of the total pool of collagen fibrils in the patient’s gingiva, but only 25% in healthy gingiva. The patient was receiving outpatient care for follow-up every three months and surgical intervention had not been planned as long as her periodontal health would not be compromised. CONCLUSIONS: It is currently not clear whether the extent of the fibrosis had a mechanistic association with the ratio of gingival tissue re-growth in our case study. Further studies are needed to explain this association and improve the management of this condition.
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spelling pubmed-50228462016-09-20 Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence Gawron, Katarzyna Łazarz-Bartyzel, Katarzyna Fertala, Andrzej Plakwicz, Paweł Potempa, Jan Chomyszyn-Gajewska, Maria Am J Case Rep Articles Patient: Female, 11 Final Diagnosis: Hereditary gingival fibromatosis Symptoms: Gingival overgrowth Medication: — Clinical Procedure: Surgery Specialty: Dentistry OBJECTIVE: Rare disease BACKGROUND: Hereditary gingival fibromatosis is characterized by slowly progressive enlargement of the gingiva that can present as an isolated condition or a part of various syndromes. CASE REPORT: An 11-year-old female reported with a gingival lesion that caused masticatory problems and poor oral hygiene. Periodontal examination revealed a dense tissue covering 30% of her teeth crowns within both jaws. Panoramic x-ray showed a normal bone height and teeth positioning. The patient did not use any medications, but a similar condition was also present in other family members. The patient was diagnosed with hereditary gingival fibromatosis. Surgery was carried out to remove excess of gingival tissue. Post-surgical healing was uneventful, but four weeks after the first surgery, the condition recurred amounting to 45% of the initial tissue volume presenting in the mandible, and 25% in the maxilla. Two months later, no significant growth was noted in the mandible, while in the maxilla, growth increased to 40% of the pre-operative state. Analysis by polarized microscope showed a significant increase of thin fibrotic fibrils that contributed 80% of the total pool of collagen fibrils in the patient’s gingiva, but only 25% in healthy gingiva. The patient was receiving outpatient care for follow-up every three months and surgical intervention had not been planned as long as her periodontal health would not be compromised. CONCLUSIONS: It is currently not clear whether the extent of the fibrosis had a mechanistic association with the ratio of gingival tissue re-growth in our case study. Further studies are needed to explain this association and improve the management of this condition. International Scientific Literature, Inc. 2016-09-09 /pmc/articles/PMC5022846/ /pubmed/27609299 http://dx.doi.org/10.12659/AJCR.899997 Text en © Am J Case Rep, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
spellingShingle Articles
Gawron, Katarzyna
Łazarz-Bartyzel, Katarzyna
Fertala, Andrzej
Plakwicz, Paweł
Potempa, Jan
Chomyszyn-Gajewska, Maria
Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence
title Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence
title_full Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence
title_fullStr Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence
title_full_unstemmed Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence
title_short Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence
title_sort gingival fibromatosis with significant de novo formation of fibrotic tissue and a high rate of recurrence
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022846/
https://www.ncbi.nlm.nih.gov/pubmed/27609299
http://dx.doi.org/10.12659/AJCR.899997
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