Protein Profiling of Bladder Urothelial Cell Carcinoma

This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and h...

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Detalles Bibliográficos
Autores principales: Hu, Jinghai, Ye, Fei, Cui, Miao, Lee, Peng, Wei, Chengguo, Hao, Yuanyuan, Wang, Xiaoqing, Wang, Yanbo, Lu, Zhihua, Galsky, Matthew, McBride, Russell, Wang, Li, Wang, Dongwen, Cordon-Cardo, Carlos, Wang, Chunxi, Zhang, David Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023150/
https://www.ncbi.nlm.nih.gov/pubmed/27626805
http://dx.doi.org/10.1371/journal.pone.0161922
Descripción
Sumario:This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival.

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