Protein Profiling of Bladder Urothelial Cell Carcinoma

This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and h...

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Autores principales: Hu, Jinghai, Ye, Fei, Cui, Miao, Lee, Peng, Wei, Chengguo, Hao, Yuanyuan, Wang, Xiaoqing, Wang, Yanbo, Lu, Zhihua, Galsky, Matthew, McBride, Russell, Wang, Li, Wang, Dongwen, Cordon-Cardo, Carlos, Wang, Chunxi, Zhang, David Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023150/
https://www.ncbi.nlm.nih.gov/pubmed/27626805
http://dx.doi.org/10.1371/journal.pone.0161922
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author Hu, Jinghai
Ye, Fei
Cui, Miao
Lee, Peng
Wei, Chengguo
Hao, Yuanyuan
Wang, Xiaoqing
Wang, Yanbo
Lu, Zhihua
Galsky, Matthew
McBride, Russell
Wang, Li
Wang, Dongwen
Cordon-Cardo, Carlos
Wang, Chunxi
Zhang, David Y.
author_facet Hu, Jinghai
Ye, Fei
Cui, Miao
Lee, Peng
Wei, Chengguo
Hao, Yuanyuan
Wang, Xiaoqing
Wang, Yanbo
Lu, Zhihua
Galsky, Matthew
McBride, Russell
Wang, Li
Wang, Dongwen
Cordon-Cardo, Carlos
Wang, Chunxi
Zhang, David Y.
author_sort Hu, Jinghai
collection PubMed
description This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival.
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spelling pubmed-50231502016-09-27 Protein Profiling of Bladder Urothelial Cell Carcinoma Hu, Jinghai Ye, Fei Cui, Miao Lee, Peng Wei, Chengguo Hao, Yuanyuan Wang, Xiaoqing Wang, Yanbo Lu, Zhihua Galsky, Matthew McBride, Russell Wang, Li Wang, Dongwen Cordon-Cardo, Carlos Wang, Chunxi Zhang, David Y. PLoS One Research Article This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival. Public Library of Science 2016-09-14 /pmc/articles/PMC5023150/ /pubmed/27626805 http://dx.doi.org/10.1371/journal.pone.0161922 Text en © 2016 Hu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hu, Jinghai
Ye, Fei
Cui, Miao
Lee, Peng
Wei, Chengguo
Hao, Yuanyuan
Wang, Xiaoqing
Wang, Yanbo
Lu, Zhihua
Galsky, Matthew
McBride, Russell
Wang, Li
Wang, Dongwen
Cordon-Cardo, Carlos
Wang, Chunxi
Zhang, David Y.
Protein Profiling of Bladder Urothelial Cell Carcinoma
title Protein Profiling of Bladder Urothelial Cell Carcinoma
title_full Protein Profiling of Bladder Urothelial Cell Carcinoma
title_fullStr Protein Profiling of Bladder Urothelial Cell Carcinoma
title_full_unstemmed Protein Profiling of Bladder Urothelial Cell Carcinoma
title_short Protein Profiling of Bladder Urothelial Cell Carcinoma
title_sort protein profiling of bladder urothelial cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023150/
https://www.ncbi.nlm.nih.gov/pubmed/27626805
http://dx.doi.org/10.1371/journal.pone.0161922
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