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Ciona as a Simple Chordate Model for Heart Development and Regeneration
Cardiac cell specification and the genetic determinants that govern this process are highly conserved among Chordates. Recent studies have established the importance of evolutionarily-conserved mechanisms in the study of congenital heart defects and disease, as well as cardiac regeneration. As a bas...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023151/ https://www.ncbi.nlm.nih.gov/pubmed/27642586 http://dx.doi.org/10.3390/jcdd3030025 |
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author | Evans Anderson, Heather Christiaen, Lionel |
author_facet | Evans Anderson, Heather Christiaen, Lionel |
author_sort | Evans Anderson, Heather |
collection | PubMed |
description | Cardiac cell specification and the genetic determinants that govern this process are highly conserved among Chordates. Recent studies have established the importance of evolutionarily-conserved mechanisms in the study of congenital heart defects and disease, as well as cardiac regeneration. As a basal Chordate, the Ciona model system presents a simple scaffold that recapitulates the basic blueprint of cardiac development in Chordates. Here we will focus on the development and cellular structure of the heart of the ascidian Ciona as compared to other Chordates, principally vertebrates. Comparison of the Ciona model system to heart development in other Chordates presents great potential for dissecting the genetic mechanisms that underlie congenital heart defects and disease at the cellular level and might provide additional insight into potential pathways for therapeutic cardiac regeneration. |
format | Online Article Text |
id | pubmed-5023151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-50231512016-09-14 Ciona as a Simple Chordate Model for Heart Development and Regeneration Evans Anderson, Heather Christiaen, Lionel J Cardiovasc Dev Dis Review Cardiac cell specification and the genetic determinants that govern this process are highly conserved among Chordates. Recent studies have established the importance of evolutionarily-conserved mechanisms in the study of congenital heart defects and disease, as well as cardiac regeneration. As a basal Chordate, the Ciona model system presents a simple scaffold that recapitulates the basic blueprint of cardiac development in Chordates. Here we will focus on the development and cellular structure of the heart of the ascidian Ciona as compared to other Chordates, principally vertebrates. Comparison of the Ciona model system to heart development in other Chordates presents great potential for dissecting the genetic mechanisms that underlie congenital heart defects and disease at the cellular level and might provide additional insight into potential pathways for therapeutic cardiac regeneration. MDPI 2016-08-09 /pmc/articles/PMC5023151/ /pubmed/27642586 http://dx.doi.org/10.3390/jcdd3030025 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Evans Anderson, Heather Christiaen, Lionel Ciona as a Simple Chordate Model for Heart Development and Regeneration |
title | Ciona as a Simple Chordate Model for Heart Development and Regeneration |
title_full | Ciona as a Simple Chordate Model for Heart Development and Regeneration |
title_fullStr | Ciona as a Simple Chordate Model for Heart Development and Regeneration |
title_full_unstemmed | Ciona as a Simple Chordate Model for Heart Development and Regeneration |
title_short | Ciona as a Simple Chordate Model for Heart Development and Regeneration |
title_sort | ciona as a simple chordate model for heart development and regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023151/ https://www.ncbi.nlm.nih.gov/pubmed/27642586 http://dx.doi.org/10.3390/jcdd3030025 |
work_keys_str_mv | AT evansandersonheather cionaasasimplechordatemodelforheartdevelopmentandregeneration AT christiaenlionel cionaasasimplechordatemodelforheartdevelopmentandregeneration |