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Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration

Over the last decade, the noncoding part of the genome has been shown to harbour thousands of cis-regulatory elements, such as enhancers, that activate well-defined gene expression programs. Driven by the development of numerous techniques, many of these elements are now identified in multiple tissu...

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Detalles Bibliográficos
Autores principales: Vermunt, Marit W., Creyghton, Menno P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023742/
https://www.ncbi.nlm.nih.gov/pubmed/27628759
http://dx.doi.org/10.1007/s11910-016-0689-7
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author Vermunt, Marit W.
Creyghton, Menno P.
author_facet Vermunt, Marit W.
Creyghton, Menno P.
author_sort Vermunt, Marit W.
collection PubMed
description Over the last decade, the noncoding part of the genome has been shown to harbour thousands of cis-regulatory elements, such as enhancers, that activate well-defined gene expression programs. Driven by the development of numerous techniques, many of these elements are now identified in multiple tissues and cell types, and their characteristics as well as importance in development and disease are becoming increasingly clear. Here, we provide an overview of the insights that were gained from the analysis of noncoding gene regulatory elements in the brain and describe their potential contribution to cell type specialization, brain function and neurodegenerative disease.
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spelling pubmed-50237422016-10-09 Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration Vermunt, Marit W. Creyghton, Menno P. Curr Neurol Neurosci Rep Genetics (V Bonifati, Section Editor) Over the last decade, the noncoding part of the genome has been shown to harbour thousands of cis-regulatory elements, such as enhancers, that activate well-defined gene expression programs. Driven by the development of numerous techniques, many of these elements are now identified in multiple tissues and cell types, and their characteristics as well as importance in development and disease are becoming increasingly clear. Here, we provide an overview of the insights that were gained from the analysis of noncoding gene regulatory elements in the brain and describe their potential contribution to cell type specialization, brain function and neurodegenerative disease. Springer US 2016-09-14 2016 /pmc/articles/PMC5023742/ /pubmed/27628759 http://dx.doi.org/10.1007/s11910-016-0689-7 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Genetics (V Bonifati, Section Editor)
Vermunt, Marit W.
Creyghton, Menno P.
Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration
title Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration
title_full Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration
title_fullStr Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration
title_full_unstemmed Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration
title_short Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration
title_sort transcriptional dynamics at brain enhancers: from functional specialization to neurodegeneration
topic Genetics (V Bonifati, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023742/
https://www.ncbi.nlm.nih.gov/pubmed/27628759
http://dx.doi.org/10.1007/s11910-016-0689-7
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